Use of cereal fiber to facilitate adherence to a human caloric restriction program.
Use of cereal fiber to facilitate adherence to a human caloric restriction program.
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DOI：
10.1007/bf03324878
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发表时间：
2008-12
影响因子：
4
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中科院分区：
文献类型：
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在动物模型中，热量限制（CR）可以减轻生物衰老，但关于CR方案在人类中的可行性和有效性的信息很少。我们研究了食用不溶性谷物纤维补充剂对健康超重成年人维持CR超过1年的能力的影响。在34名健康超重女性和男性（BMI 25-30 kg/m2，年龄20-42岁）中，提供了符合国家膳食纤维建议的30% CR方案24周，并建议受试者在家中准备相同的方案。在5-10周的CR期间，受试者被随机分配从高纤维谷物中额外摄入20 g/天的膳食纤维（+F）或不摄入额外的纤维（-F）。在此之后，鼓励所有受试者消耗额外的纤维。结果包括对提供的和自行准备的CR方案的依从性（使用双标记水确定能量摄入）、体重变化和自我报告的对食物摄入量的满意度。在CR的5-10周期间，当提供所有食物时，+F和−F组都高度遵守CR方案，两组之间的能量摄入（p=0.51），体重变化（p=0.96）或对所提供食物量的满意度（p=0.08）没有显著差异。在25 - 48周的自制CR期间，平均依从性低于食物提供阶段，纤维摄入量与% CR（r=0.69，p<0.001）、BMI降低（r=-0.38，p=0.04）和对食物摄入量的满意度（r=0.59，p=0.002）之间存在显著相关性。高纤维谷物摄入可能有助于人类自我选择食物的CR;需要长期干预研究来证实这些发现。
Caloric restriction (CR) attenuates biological aging in animal models but there is little information on the feasibility and efficacy of CR regimens in humans. We examined the effects of consuming an insoluble cereal fiber supplement on ability to sustain CR over 1 year in healthy overweight adults. In 34 healthy overweight women and men (BMI 25–30 kg/m2, age 20–42 yr), a 30% CR regimen meeting national recommendations for dietary fiber was provided for 24 weeks, and for an additional 24 weeks subjects were counseled to prepare the same regimen at home. During 5–10 weeks of CR, subjects were randomized to consume an extra 20 g/day of dietary fiber from a high fiber cereal (+F) or to not consume additional fiber (−F). After this time, all subjects were encouraged to consume the extra fiber. Outcomes included adherence to the provided and self-prepared CR regimens (energy intake determined using doubly labeled water), changes in body weight, and self-reported satisfaction with the amount of consumed food. During 5–10 weeks of CR when all food was provided, both +F and −F groups were highly adherent to the CR regimen and there was no significant difference between groups in energy intake (p=0.51), weight change (p=0.96), or satisfaction with amount of provided food (p=0.08). During self-prepared CR from 25 to 48 weeks, mean adherence was lower than during the food-provided phase and there was a significant association between fiber intake and % CR (r=0.69, p<0.001), decreased BMI (r=-0.38, p=0.04) and satisfaction with the amount of consumed food (r=0.59, p=0.002). A high fiber cereal intake may facilitate CR in humans self-selecting their own food; longer-term intervention studies are needed to confirm these findings.