Novel feedback loop between M2 macrophages/microglia and regulatory B cells in estrogen-protected EAE mice.
Novel feedback loop between M2 macrophages/microglia and regulatory B cells in estrogen-protected EAE mice.
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DOI：
10.1016/j.jneuroim.2016.12.018
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发表时间：
2017-04-15
影响因子：
3.3
通讯作者：
Offner H
中科院分区：
文献类型：
--
作者：
Benedek G;Zhang J;Nguyen H;Kent G;Seifert H;Vandenbark AA;Offner H
免疫调节性激素，包括雌激素和雌三醇，可以防止多发性硬化症在怀孕期间复发。我们以前的研究表明，调节性B细胞是至关重要的雌激素介导的保护，对实验性自身免疫性脑脊髓炎（EAE）。在此，我们证明了雌激素依赖性诱导的交替激活（M2）的巨噬细胞/小胶质细胞，导致在增加的频率调节B细胞在脊髓中的雌激素治疗EAE小鼠。我们进一步证明了培养的M2极化小胶质细胞促进调节性B细胞的诱导。我们的研究表明，雌激素神经保护诱导M2巨噬细胞/小胶质细胞和调节B细胞之间的调节反馈回路。
Immunoregulatory sex hormones, including estrogen and estriol, may prevent relapses in multiple sclerosis during pregnancy. Our previous studies have demonstrated that regulatory B cells are crucial for estrogen-mediated protection against experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate an estrogen-dependent induction of alternatively activated (M2) macrophages/microglia that results in an increased frequency of regulatory B cells in the spinal cord of estrogen treated mice with EAE. We further demonstrate that cultured M2-polarized microglia promote the induction of regulatory B cells. Our study suggests that estrogen neuroprotection induces a regulatory feedback loop between M2 macrophages/microglia and regulatory B cells.