FV-1 restriction of age-dependent paralytic lactic dehydrogenase virus infection.
FV-1 restriction of age-dependent paralytic lactic dehydrogenase virus infection.
复制标题
FV-1 限制年龄依赖性麻痹性乳酸脱氢酶病毒感染。
DOI：
10.1016/0042-6822(82)90504-9
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发表时间：
1982
期刊：
影响因子：
3.7
通讯作者：
Murphy,WH
中科院分区：
文献类型：
--
作者：
Pease,LR;Abrams,GD;Murphy,WH
本文对近交系小鼠对一种神经麻痹性乳酸脱氢酶病毒毒株ip注射引起的麻痹性疾病的易感性进行了遗传分析。易感近交系小鼠的发病频率与x射线剂量和年龄有关。对合适的f1杂交种及其回交后代的易感性分析表明，易感性与主要组织相容性复合体无关，而与Fv-1连锁组分离。连锁组分析表明，对麻痹性感染的抗性与主要组织相容性复合体外的单个基因有关。通过测定gpd -1同工酶变异在回交后代中的分离情况，表明fv -1等位基因的遗传实际上导致了对易感性的绝对限制。获得的遗传证据表明，在小鼠基因组中具有多个嗜n型c型逆转录病毒拷贝且允许逆转录病毒表达（Fv-1n/n）的小鼠易患麻痹性LDV感染。在其基因组中携带少量嗜n型c型逆转录病毒拷贝的菌株，或遗传了fv -1ballele的菌株，具有耐药性。在一些回交代中，母体的显著抗性效应被证明是由主要组织相容性复合体h -2bin介导的。
A genetic analysis was made of the susceptibility of inbred mice to a paralytic disease elicited by the ip injection of a neuroparalytic strain of lactic dehydrogenase virus. The frequency of disease in susceptible inbred mice was X-ray dose and age dependent. Analysis of the susceptibility of appropriate F1hybrids and their backcross progeny showed that susceptibility was not linked to the major histocompatibility complex but segregated with the Fv-1 linkage group. Linkage group analysis showed that resistance to paralytic infection was linked to a single gene outside the major histocompatibility complex. By determining the segregation ofGpd-1isozyme variants among backcross progeny it was shown that inheritance of theFv-1ballele resulted in virtually absolute restriction of susceptibility. Genetic evidence was obtained indicating that mice that mice that had multiple copies of N-tropic C-type retroviruses in their genomes, and that were permissive for retrovirus expression (Fv-1n/n), were susceptible to paralytic LDV infection. Strains that carried few copies of N-tropic C-type retroviruses in their genomes, or that inherited theFv-1ballele, were resistant. A significant maternal resistance effect was demonstrable in some backcross generations that appeared to be mediated byH-2bin the major histocompatibility complex.