Positive association between congenital anomalies and risk of neuroblastoma
Positive association between congenital anomalies and risk of neuroblastoma
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DOI：
10.1002/pbc.20263
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发表时间：
2005-10-15
影响因子：
3.2
通讯作者：
Cohn, SL
中科院分区：
文献类型：
--
作者：
Menegaux, F;Olshan, AF;Cohn, SL
背景病例报告和流行病学研究表明先天性异常和儿童癌症之间存在关系，但一些潜在的联系仍然不一致。在这项研究中，我们调查了先天性异常和神经母细胞瘤之间的关系。Procedure.我们使用了1992年至1994年进行的神经母细胞瘤病例对照研究的数据，其中包括538名年龄在0-19岁之间的新诊断的、经组织学证实的神经母细胞瘤儿童和504名通过电话随机数字拨号识别并与出生日期匹配的病例对照。先天性异常和潜在的混杂因素的信息是通过母亲电话访谈使用结构化问卷收集的。我们估计了比值比（OR）和95%置信区间（CI），并根据诊断时的参考年龄、母亲的教育水平、母亲的种族和出生时的家庭收入进行了调整。结果观察到母亲报告的任何先天性异常与神经母细胞瘤之间存在关联（OR= 2.58; CI = 1.57-4.25）。神经母细胞瘤风险随着每个孩子异常数量的增加而增加（OR = 3.90，Cl = 1.27-11.9，对于两个或更多异常），当我们将分析限制在主要异常时（OR - 7.53，Cl - 2.23-25.5）。泌尿生殖系统异常（OR = 5.84，CI = 1.6720.4）和心脏异常（OR= 4.27，CI = 1.22-15.0）的神经母细胞瘤风险升高，但不精确。结论.我们的研究结果支持神经母细胞瘤与先天性，特别是泌尿生殖系统和心脏畸形之间存在关联的假设。
Background Case reports and epidemiological studies have suggested a relationship between congenital anomalies and childhood cancer, but some potential associations remain inconsistent. In this study, we investigated the association between congenital anomalies and neuroblastoma. Procedure. We used data of a case-control study on neuroblastoma conducted from 1992 to 1994, including 538 children aged 0-19 years with newly diagnosed, histologically confirmed neuroblastoma and 504 controls identified by telephone random-digit dialing and matched to cases on date of birth. information on congenital anomalies and potential confounding factors was collected through maternal telephone interviews using a structured questionnaire. We estimated odds ratios (OR) and 95% confidence intervals (CI), adjusted for reference age at diagnosis, mother's educational level, mother's race, and household income at birth. Results. An association between the maternal report of any congenital anomalies and neuroblastorna (OR= 2.58; Cl = 1.57-4.25) was observed. Neuroblastoma risk increased with increasing number of anomalies per child (OR = 3.90, Cl = 1.27-11.9 for two anomalies or more), and when we restricted analyses to major anomalies (OR - 7.53, Cl - 2.23-25.5). Genitourinary anomalies (OR = 5.84, Cl = 1.6720.4) and cardiac anomalies (OR= 4.27, Cl = 1.22-15.0) had an elevated, but imprecise neuroblastoma risk. Conclusions. Our findings support the hypothesis of an association between neuroblastoma and congenital, especially urogenital and cardiac, anomalies.