Evaluation of clinical activity and functional impairment in smokers with Ankylosing spondylitis
Evaluation of clinical activity and functional impairment in smokers with Ankylosing spondylitis
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DOI：
10.1007/s00296-004-0451-3
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发表时间：
2005-07-01
影响因子：
4
通讯作者：
Ferda, Ö
中科院分区：
文献类型：
--
作者：
Kaan, U;Ferda, Ö
背景资料：强直性脊柱炎（AS）是一种风湿性疾病，使人类在其生命的最具生产力的阶段丧失能力，引起功能障碍，从而影响患者及其亲属。疾病活动性、功能损害和治疗效果受到各种环境和遗传因素的影响，其中之一是吸烟。我们研究了吸烟对AS临床活动和功能损害的影响。患者和方法：本研究纳入了48例背痛和活动受限的患者，这些患者根据临床、放射学和实验室检查诊断为AS，并转诊至土耳其Trakya大学医学院物理医学和康复系。疾病活动性用Bath强直性脊柱炎疾病活动指数（BASDAI）评估，功能损害用Bath强直性脊柱炎功能指数（BASFI）评估。Mann-Whitney U检验用于确定吸烟与体格检查结果、实验室检查结果以及BASDAI和BASFI评分之间的关系。结果：24例患者为吸烟者。他们的BASDAI和BASFI评分显著高于非吸烟者，用力肺活量值显著低于非吸烟者（分别为P = 0.000，P = 0.002和P = 0.001）（Mann-Whitney U检验）。结论：吸烟与AS的临床表现和功能损害有关。潜在的机制可能是吸烟导致的身体机能丧失。
Background: Ankylosing spondylitis (AS), a rheumatic disease, incapacitates human beings during the most productive stage of their lives, causes functional disturbances, and thus affects both patients and their relatives. Disease activity, functional impairment, and efficacy of treatment are affected by various environmental and genetic factors, one of which is smoking. We investigated smoking's effect on clinical activity and functional impairment in AS. Patients and methods: Forty-eight patients with back pain and limited movements, diagnosed with AS based on clinical, radiological, and laboratory examinations and referred to the Trakya University School of Medicine Physical Medicine and Rehabilitation Department in Turkey were included in this study. Disease activity was evaluated with the Bath Ankylosing Spondylitis Disease Activity Index ( BASDAI) and functional impairment with the Bath Ankylosing Spondylitis Functional Index (BASFI). The Mann-Whitney U test was used to determine relationships between smoking and physical findings, laboratory results, and BASDAI and BASFI scores. Results: Twenty-four patients were smokers. They had significantly higher BASDAI and BASFI scores and significantly lower forced vital capacity values than nonsmokers (P = 0.000, P = 0.002, and P = 0.001, respectively) ( Mann-Whitney U test). Conclusion: Smoking is associated with poor clinical aspect and functional impairment in AS. The underlying mechanism can be the physical incapacity caused by smoking.