Association of abdominal muscle composition with prediabetes and diabetes: The CARDIA study
Association of abdominal muscle composition with prediabetes and diabetes: The CARDIA study
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DOI：
10.1111/dom.13513
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发表时间：
2019-02-01
影响因子：
5.8
通讯作者：
Lee, Joyce M.
中科院分区：
文献类型：
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作者：
Granados, Andrea;Gebremariam, Achamyeleh;Lee, Joyce M.
目的探讨糖尿病前期及糖尿病患者腹部肌肉、脂肪组织体积的变化。研究设计和方法我们测量了3170名年轻人冠状动脉风险发展（CARDIA）研究参与者的腹肌组成，这些参与者在随访25年（年龄，43-55岁）时接受了计算机断层扫描（CT）。采用多项式回归分析评价CARDIA研究期间任何时间点CT测量的肌间脂肪组织（IMAT）、瘦肉组织（lean）和内脏脂肪组织（VAT）体积与糖尿病、新检测到的前驱糖尿病、前驱糖尿病既往史和正常葡萄糖耐量的相关性。针对潜在混杂因素调整模型：年龄、性别、人种、身高、吸烟状况、高血压、高血脂、心肺功能和研究中心。结果IMAT、瘦体重和VAT均与糖尿病前期和糖尿病的患病率相关。在具有IMAT体积和瘦体积的模型中包括VAT体积减弱了IMAT与前驱糖尿病和糖尿病的关联，但较高的瘦体积保留了其与前驱糖尿病和糖尿病的关联。IMAT最高四分位数加上增值税在较低三个四分位数的个体，与IMAT和增值税均在各自较低三个四分位数的个体相比，糖尿病的患病率更高，但糖尿病前期的患病率却不高。调整心肺适应性并没有实质性改变研究结果。结论：即使在调整VAT体积后，较高的IMAT体积仍与较高的糖尿病患病率相关。然而，进一步的研究是必要的，以了解腹部肌肉和脂肪组织之间的复杂关系。
Aim To evaluate the relationship of abdominal muscle lean tissue and adipose tissue volumes with prediabetes and diabetes. Research Design and Methods We measured abdominal muscle composition in 3170 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study who underwent computed tomography (CT) at Year 25 of follow-up (ages, 43-55 years). Multinomial regression analysis was used to evaluate the associations of CT-measured intermuscular adipose tissue (IMAT), lean muscle tissue (lean) and visceral adipose tissue (VAT) volumes with diabetes at any point during the CARDIA study, newly detected prediabetes, prior history of prediabetes, and normal glucose tolerance. Models were adjusted for potential confounding factors: age, sex, race, height, smoking status, hypertension, hyperlipidaemia, cardiorespiratory fitness and study centre. Results Higher IMAT, lean and VAT volumes were all separately associated with a higher prevalence of prediabetes and diabetes. Inclusion of VAT volume in models with both IMAT volume and lean volume attenuated the association of IMAT with both prediabetes and diabetes, but higher lean volume retained its association with prediabetes and diabetes. Individuals in the highest IMAT quartile, coupled with VAT in its lower three quartiles, had a higher prevalence of diabetes, but not of prediabetes, than those with both IMAT and VAT in their respective lower three quartiles. Adjusting for cardiorespiratory fitness did not substantially change the findings. Conclusion Higher IMAT volume was associated with a higher prevalence of diabetes even after adjustment for VAT volume. However, further study is warranted to understand the complicated relationship between abdominal muscle and adipose tissues.