Evaluation of a post-processing approach for multiscale analysis of biphasic mechanics of chondrocytes, DOI: 10.1080/10255842.2013.809711.
Evaluation of a post-processing approach for multiscale analysis of biphasic mechanics of chondrocytes, DOI: 10.1080/10255842.2013.809711.
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软骨细胞双相力学多尺度分析的后处理方法评估，DOI：10.1080/10255842.2013.809711。
DOI：
10.1080/10255842.2013.869043
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发表时间：
2016
影响因子：
1.6
通讯作者：
Erdemir,Ahmet
中科院分区：
文献类型：
--
作者：
Sibole,ScottC;Maas,Steve;Halloran,JasonP;Weiss,JeffreyA;Erdemir,Ahmet
了解软骨组织力学的结果，软骨细胞的力学行为有显着的影响，既评价机械生物学功能，并阐述损伤机制。预测软骨细胞力学（以及一般细胞力学）的常见程序依赖于计算后处理方法，其中组织水平的变形驱动细胞水平的模型。这种数值耦合方法中的潜在信息丢失可能会导致错误的细胞尺度结果，特别是在软骨的多物理场分析期间。本研究的目的是评估能力的一阶和二阶数据通过分析软骨变形获得不同的复杂性的负载情况下预测软骨细胞力学。一个组织规模的模型与一个子区域纳入代表性的软骨大小和分布作为控制。后处理方法首先需要解决一个均匀的组织水平的模型，其结果被用来驱动一个单独的细胞水平的模型（相同的特性作为控制模型的子区域）。一阶数据传递似乎足以简化软骨的加载和细胞变形度量的子集，例如，纵横比的变化。二阶数据传递方案更准确，特别是当考虑组织边界的非对称渗透性时。然而，该方法表现出与流体相，例如，质量交换率的瞬时指标的预测的局限性。尽管如此，采用更高阶的数据交换方案可能是必要的，以了解逼真的组织加载状态下的模拟的整个时间历史的细胞的双相力学。
Understanding the mechanical behaviour of chondrocytes as a result of cartilage tissue mechanics has significant implications for both evaluation of mechanobiological function and to elaborate on damage mechanisms. A common procedure for prediction of chondrocyte mechanics (and of cell mechanics in general) relies on a computational post-processing approach where tissue-level deformations drive cell-level models. Potential loss of information in this numerical coupling approach may cause erroneous cellular-scale results, particularly during multiphysics analysis of cartilage. The goal of this study was to evaluate the capacity of first- and second-order data passing to predict chondrocyte mechanics by analysing cartilage deformations obtained for varying complexity of loading scenarios. A tissue-scale model with a sub-region incorporating representation of chondron size and distribution served as control. The post-processing approach first required solution of a homogeneous tissue-level model, results of which were used to drive a separate cell-level model (same characteristics as the sub-region of control model). The first-order data passing appeared to be adequate for simplified loading of the cartilage and for a subset of cell deformation metrics, for example, change in aspect ratio. The second-order data passing scheme was more accurate, particularly when asymmetric permeability of the tissue boundaries was considered. Yet, the method exhibited limitations for predictions of instantaneous metrics related to the fluid phase, for example, mass exchange rate. Nonetheless, employing higher order data exchange schemes may be necessary to understand the biphasic mechanics of cells under lifelike tissue loading states for the whole time history of the simulation.