PRENATAL DEVELOPMENT OF NEURONS IN THE HUMAN PREFRONTAL CORTEX .2. A QUANTITATIVE GOLGI-STUDY
PRENATAL DEVELOPMENT OF NEURONS IN THE HUMAN PREFRONTAL CORTEX .2. A QUANTITATIVE GOLGI-STUDY
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DOI：
10.1002/cne.903160408
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发表时间：
1992-02-22
影响因子：
2.5
通讯作者：
VANEDEN, CG
中科院分区：
文献类型：
--
作者：
MRZLJAK, L;UYLINGS, HBM;VANEDEN, CG
在人背外侧和外侧前额叶皮层神经元的定量发展进行了研究高尔基浸渍组织从死后的大脑范围从13.5周的怀孕到第二个月出生后。锥体神经元在未来层III和V的皮质板，以及不同类型的神经元在瞬态subplate区，进行了研究。未来的第III层和第V层锥体神经元的基底树突在妊娠期的前三分之二显示出缓慢的增加。从孕27-32周开始，第III层和第V层锥体神经元的基底树突长度迅速增加，而每个锥体神经元的基底树突数量在孕26/27周时似乎稳定下来。每个锥体神经元的基底树突总长度的增加主要是由于分叉数量的增加和终末节的生长。在整个研究期间，第III层锥体基底树突树的大小小于第V层锥体神经元。因此，直到出生后的生活做第三层锥体基底树突变得大于第五层。没有统计学上的显着差异被发现的数据之间的锥体神经元的上级和额中回。亚板神经元的树突的大小，除了亚板倒锥体神经元，显着超过锥体神经元的基底树突的大小到第七个月的妊娠，这表明这些亚板神经元的成熟较早。在检查期间，未观察到亚板神经元的大小明显减少。本研究表明，无论是subplate或皮质板锥体神经元的树突参数迅速增加期间的传入纤维向内生长到subplate区和皮质板，分别。在前额叶皮层的高尔基体制备中，基板神经元的大小在产前期结束时没有显示出任何明显的回归变化。
The quantitative development of neurons in the human dorsolateral and lateral prefrontal cortex was studied in Golgi-impregnated tissue from postmortem brains ranging from 13.5 weeks of gestation up to the second postnatal month. Pyramidal neurons in the future layers III and V of the cortical plate, as well as different types of neurons in the transient subplate zone, were studied. The basal dendrites of the future layer III and V pyramidal neurons show a slow increase during the first two-thirds of the period of gestation. From 27-32 weeks of gestation on, there is a rapid increase in the length of basal dendrites of layer III and V pyramidal neurons, while the number of basal dendrites per pyramidal neuron appears to stabilize at 26/27 weeks of gestation. The increase in total length of basal dendrites per pyramidal neuron is mainly due to an increase in the number of bifurcations and the growth of terminal segments. Throughout the whole period studied, the size of the layer III pyramidal basal dendritic tree was smaller than that of layer V pyramidal neurons. Thus, not until postnatal life do the layer III pyramidal basal dendrites become larger than those of layer V. No statistically significant differences were found for data of the pyramidal neurons between the superior and middle frontal gyri. The dendritic size of subplate neurons, except for the subplate inverted pyramidal neurons, significantly exceeds the size of the basal dendrites of the pyramidal neurons up to the seventh gestational month, which indicates an earlier maturation of these subplate neurons. During the period examined, no clear decrease in the size of the subplate neurons was observed. The present study shows that the dendritic parameters of either subplate or cortical plate pyramidal neurons rapidly increase during the periods of ingrowth of afferent fibers into the subplate zone and cortical plate, respectively. In the Golgi preparations of the prefrontal cortex, the size of the subplate neurons does not show any clearly regressive changes at the end of the prenatal period.