Calretinin expression in hilar mossy cells of the hippocampal dentate gyrus of nonhuman primates and humans.
Calretinin expression in hilar mossy cells of the hippocampal dentate gyrus of nonhuman primates and humans.
复制标题
钙结合蛋白在非人灵长类动物和人类海马齿状回的门苔细胞中的表达。
DOI：
10.1002/hipo.20403
复制
发表时间：
2008
期刊：
影响因子：
3.5
通讯作者：
Leranth,Csaba
中科院分区：
文献类型：
--
作者：
Seress,Laszlo;Abraham,Hajnalka;Czeh,Boldizsar;Fuchs,Eberhard;Leranth,Csaba
苔藓细胞是齿状回门的主要兴奋性神经元，在几种啮齿动物（包括小鼠和仓鼠）中组成型表达钙结合蛋白，但在大鼠中不表达。几项研究表明，猴子齿状回的苔藓细胞呈钙结合蛋白阳性，但其他研究报告猴子的苔藓细胞缺乏可检测到的钙结合蛋白样免疫反应性。在本研究中，对旧世界和新世界猴子以及人类的海马齿状回的整个纵向范围内的肺门区域进行了研究。在所检查的四种猴子中，发现苔藓细胞在钩端和齿状回主体内不同长度处呈钙视网膜素阳性，但在尾部则不然。由内齿状分子层中的苔藓细胞轴突形成的关联途径在更多尾部部分呈钙视网膜素阳性，这表明苔藓细胞轴突末端可能含有钙视网膜素，而苔藓细胞胞体可能含有浓度太低而无法通过免疫细胞化学检测到的钙视网膜素。相比之下，人类苔藓细胞的体细胞和轴突末端似乎都缺乏钙视网膜素免疫反应性。总而言之，非人类灵长类动物和人类的苔藓细胞表现出不同的钙视网膜蛋白表达模式，而它们在神经化学成分（例如可卡因和安非他明相关转录肽）方面表现出相似性。 © 2008 Wiley-Liss, Inc.
Mossy cells, the major excitatory neurons of the hilus of the dentate gyrus constitutively express calretinin in several rodent species, including mouse and hamster, but not in rats. Several studies suggest that mossy cells of the monkey dentate gyrus are calretinin‐positive, but others have reported mossy cells in monkeys to be devoid of detectable calretinin‐like immunoreactivity. In the present study, the hilar region was investigated throughout the entire longitudinal extent of the hippocampal dentate gyrus in both Old World and New World monkeys, as well as in humans. In the examined four monkey species, mossy cells were found to be calretinin‐positive at the uncal pole and at variable length within the main body of the dentate gyrus but not in the tail part. The associational pathway, formed by axons of mossy cells in the inner dentate molecular layer was calretinin‐positive in more caudal sections, suggesting that mossy cell axon terminals may contain calretinin, whereas mossy cell somata may contain calretinin in a concentration too low to be detected by immunocytochemistry. In contrast, human mossy cells appear to be devoid of calretinin immunoreactivity in both their somata and their axon terminals. Taken together, mossy cells of nonhuman primates and humans exhibit different expression pattern for calretinin whereas they show similarities in neurochemical content, such as the cocaine and amphetamine‐related transcript peptide. © 2008 Wiley‐Liss, Inc.