Severity in sustained attention impairment and clozapine-resistant schizophrenia: a retrospective study
Severity in sustained attention impairment and clozapine-resistant schizophrenia: a retrospective study
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持续注意力障碍和氯氮平耐药性精神分裂症的严重程度：一项回顾性研究
DOI：
10.1186/s12888-019-2204-6
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发表时间：
2019
期刊：
影响因子：
4.4
通讯作者：
Wei J. Chen
中科院分区：
文献类型：
--
作者：
An;H. Chan;Ying;Wei J. Chen
BackgroundAmong patients with treatment-resistant schizophrenia (TRS), some exhibited further clozapine resistance (CR). This study aimed to investigate whether greater severity of treatment resistance in schizophrenia is associated with greater impairments in sustained attention.MethodsPatients with a DSM-IV-defined schizophrenia were recruited from a psychiatric center in northern Taiwan (April 2010 to October 2010). Both TRS and CR were determined retrospectively from participants’ medical records following the consensus guidelines. The patients were divided into three groups: 102 non-TRS, 48 TRS without CR, and 54 TRS with CR. They underwent both undegraded and degraded Continuous Performance Tests (CPT), and their performance scores (d′) were standardized against a community sample to derive age-, sex-, and education-adjusted z scores.ResultsThe TRS with CR group had significantly lower adjusted z scores of d′ on both undegraded and degraded CPTs than the other two groups. Meanwhile, the differences between the TRS without CR group and the non-TRS group were not significant. Multivariable linear regression analyses with adjustment for covariates revealed a trend of gradient impairments on the degraded CPT from non-TRS to TRS without CR and to TRS with CR. The proportions of attentional deficits (an adjusted z score of ≤ − 2.5) on the degraded CPT also exhibited a significant trend, from 36.3% in the non-TRS group to 62.5% in the TRS without CR group and to 83.3% in the TRS with CR group.ConclusionsGreater severity of treatment resistance in schizophrenia was associated with greater impairments in sustained attention, indicating some common vulnerability.
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影响因子：
6.6
作者：
Lin, Sheng-Hsiang;Liu, Chih-Min;Chen, Wei J.
通讯作者：
Chen, Wei J.
影响因子：
--
作者：
J. Kane;G. Honigfeld;J. Singer;H. Meltzer
通讯作者：
J. Kane;G. Honigfeld;J. Singer;H. Meltzer
DOI：
--
发表时间：
2003
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
J. Kane;S. Leucht;D. Carpenter;J. Docherty
通讯作者：
J. Kane;S. Leucht;D. Carpenter;J. Docherty
影响因子：
56.9
作者：
NUECHTERLEIN, KH;PARASURAMAN, R;JIANG, Q
通讯作者：
JIANG, Q