Dietary patterns, food groups, and nutrients as predictors of plasma choline and betaine in middle-aged and elderly men and women
Dietary patterns, food groups, and nutrients as predictors of plasma choline and betaine in middle-aged and elderly men and women
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DOI：
10.3945/ajcn.2008.26531
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发表时间：
2008-12-01
影响因子：
7.1
通讯作者：
Ueland, Per M.
中科院分区：
文献类型：
--
作者：
Konstantinova, Svetlana V.;Tell, Grethe S.;Ueland, Per M.
背景：胆碱和甜菜碱与磷脂和单碳代谢有关。这些季胺的血液浓度或饮食摄入与慢性疾病的风险有关，包括心血管疾病和代谢综合征。目的：我们旨在确定从没有叶酸强化的地区招募的中老年受试者血浆胆碱和甜菜碱的饮食预测因素。设计：这是一项基于人群的研究，在霍德兰健康研究队列中，有5812名年龄在47-49岁和71-74岁的男性和女性。通过多元线性回归分析评估每增加四分位数的食物、饮料和营养素摄入的血浆浓度，并通过因子分析评估饮食模式。结果：血浆胆碱可通过鸡蛋摄入量（0.16 mu mol/L, P < 0.0001）和胆固醇摄入量（0.16 mu mol/L, P < 0.0001）预测，甜菜碱可通过高纤维面包摄入量（0.65 mu mol/L, P < 0.0001）预测；高脂乳制品（-0.70 μ mol/L, P < 0.0001）；复合碳水化合物、纤维、叶酸和硫胺素(0.66-1.44 μ mol/L
Background: Choline and betaine are linked to phospholipid and one-carbon metabolism. Blood concentrations or dietary intake of these quaternary amines have been related to the risk of chronic diseases, including cardiovascular disease and the metabolic syndrome.Objective: We aimed to determine dietary predictors of plasma choline and betaine among middle-aged and elderly subjects recruited from an area without folic acid fortification.Design: This is a population-based study of 5812 men and women aged 47-49 and 71-74 y, within the Hordaland Health Study cohort. Plasma concentrations per increasing quartile of intake of foods, beverages, and nutrients were assessed by multiple linear regression analysis, and dietary patterns were assessed by factor analysis.Results: Plasma choline was predicted by egg consumption (0.16 mu mol/L; P < 0.0001) and cholesterol intake (0.16 mu mol/L; P < 0.0001), and betaine was predicted by consumption of high-fiber bread (0.65 mu mol/L; P < 0.0001); high-fat dairy products (-0.70 mu mol/L; P < 0.0001); complex carbohydrates, fiber, folate, and thiamine (0.66-1.44 mu mol/L; P