Eicosapentaenoic acid ethyl ester ameliorates atopic dermatitis-like symptoms in special diet-fed hairless mice, partly by restoring covalently bound ceramides in the stratum corneum
Eicosapentaenoic acid ethyl ester ameliorates atopic dermatitis-like symptoms in special diet-fed hairless mice, partly by restoring covalently bound ceramides in the stratum corneum
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DOI：
10.1111/exd.13507
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发表时间：
2018-08-01
影响因子：
3.6
通讯作者：
Nabe, Takeshi
中科院分区：
文献类型：
--
作者：
Fujii, Masanori;Ohyanagi, Chie;Nabe, Takeshi
皮肤屏障功能障碍在特应性皮炎（AD）的发展中起着关键作用。共价结合的神经酰胺（Cer）是通透性屏障平衡所必需的脂质，据报道在AD患者的角质层（SC）中减少。喂食一种特殊食物的无毛老鼠会患上类似人类阿尔茨海默病的瘙痒性皮炎。我们之前的研究发现，口服n-3多不饱和脂肪酸-亚麻酸可以改善AD小鼠的皮肤屏障功能障碍，同时增加血清二十碳五烯酸（EPA）。在这项研究中，我们研究了EPA乙酯（EPA- e）对饮食诱导的无毛小鼠AD的影响。口服EPA-E可改善AD小鼠的皮肤屏障功能障碍和瘙痒。在AD小鼠SC中，共价结合的Cer明显减少。EPA-E处理恢复了约束Cer的缺失。我们的发现暗示了EPA-E在治疗人类AD方面可能的临床应用。
Skin barrier dysfunction has a key role in the development of atopic dermatitis (AD). Covalently bound ceramides (Cer), which are essential lipids for permeability barrier homoeostasis, are reportedly decreased in the stratum corneum (SC) of AD patients. Hairless mice fed a special diet develop pruritic dermatitis resembling human AD. Our previous study found that oral administration of the n-3 polyunsaturated fatty acid -linolenic acid ameliorated skin barrier dysfunction in AD mice with concomitant increase in serum eicosapentaenoic acid (EPA). In this study, we examined the effects of EPA ethyl ester (EPA-E) on diet-induced AD in hairless mice. Oral administration of EPA-E ameliorated skin barrier dysfunction and pruritus in AD mice. In the SC of AD mice, covalently bound Cer were markedly diminished. EPA-E administration restored the lack of bound Cer. Our findings imply the possible therapeutic clinical application of EPA-E in the treatment of human AD.