Growth of human glioblastomas as xenografts in the brains of athymic rats.
Growth of human glioblastomas as xenografts in the brains of athymic rats.
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DOI：
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发表时间：
2002
期刊：
影响因子：
2.3
通讯作者：
T. Ozawa;Jinglian Wang;Lily J. Hu;A. Bollen;K. Lamborn;D. Deen
中科院分区：
文献类型：
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作者：
T. Ozawa;Jinglian Wang;Lily J. Hu;A. Bollen;K. Lamborn;D. Deen
我们已经开发了人胶质母细胞瘤（GBM）的异种移植物，并建立了这些肿瘤的基线生长参数和组织病理学特征。方法将来自4种不同的人GBM细胞系的细胞注射到无胸腺大鼠的右侧尾壳核中。我们测量了每只大鼠的肿瘤重量和估计的存活时间。说明书-结论：U-251 MG和U-87 MG细胞在无胸腺大鼠的脑内产生了100%的实体瘤，而SF-767和SF-126细胞在无胸腺大鼠的脑内不生长。在所采用的条件下，U-87 MG肿瘤比U-251 MG肿瘤生长得更快，但两种类型的肿瘤在动物间均表现出可重复的生长特征。两种肿瘤类型之间的生长特征和组织学存在异质性，表明这些肿瘤模型可能有助于模拟人类GBM之间发生的一些异质性。
BACKGROUND We have developed xenografts of human glioblastoma (GBM) and established the baseline growth parameters and histopathological features of these tumors. MATERIALS-METHODS Cells from 4 different human GBM cell lines were injected into the right caudate-putamen of brain in athymic rats. We measured tumor weights and the estimated survival time of each rat. RESULTS-CONCLUSION: U-251 MG and U-87 MG cells produced solid intracerebral tumors with a 100% tumor take rate, while SF-767 and SF-126 cells did not grow in the brains of athymic rats. Under the conditions employed, U-87 MG tumors grew faster than U-251 MG tumors, but both types of tumors exhibited reproducible growth characteristics from animal to animal. There was heterogeneity in the growth characteristics and histologies between the 2 tumor types, indicating that these tumor models might be useful for simulating some of the heterogeneity that occurs between GBM in humans.