Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion
Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion
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DOI：
10.1016/j.msec.2020.111158
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发表时间：
2020-11-01
影响因子：
7.9
通讯作者：
Li, Jiang
中科院分区：
文献类型：
--
作者：
Pan, Yongsheng;Zhao, Yue;Li, Jiang
在口腔医学中，促进牙槽骨再生的同时防止牙槽嵴吸收减少仍然是一个挑战。本工作设计并制备了具有可注射、促进自愈、可降解、多孔结构等多功能的仿生多糖水凝胶，并引入纳米羟基磷灰石颗粒，制备了水凝胶/羟基磷灰石（GH）复合支架。将生长激素材料注入拔牙大鼠下颌切牙，4周后新骨面积增加50%以上，牙槽嵴增加60%以上。创面软组织均在1周内愈合。总体而言，我们的结果表明，这种优化的GH支架有潜力保持牙槽嵴的尺寸并促进软组织愈合。此外，使用含羟基磷灰石的水凝胶平台具有促进骨和软组织再生的潜力。
In stomatology, the promotion of alveolar bone regeneration while preventing the reduction of ridge absorption remains a challenge. In this work, we designed and prepared bio-mimetic polysaccharide hydrogels that are multi-functional in terms of being injectable, promote self-healing, degradable, porous structure, et al. After introducing nano-hydroxyapatite particles, the composite scaffold of hydrogel/hydroxyapatite (GH) stent was obtained. When GH material was injected into the mandibular incisors of rats following tooth extraction, the new bone area was enhanced more than 50%, while the alveolar ridge was promoted in excess of 60% after 4 weeks. What's more, the wound soft tissue was healed within 1 week. Overall, our results indicate that this optimized GH stent has the potential to both maintain dimensional alveolar ridge, as well as to promote soft tissue healing. Moreover, using the hydroxyapatite-containing hydrogel platform has the potential to promote bone and soft tissue regeneration.