MS-based metabolomics facilitates the discovery of in vivo functional small molecules with a diversity of biological contexts.
MS-based metabolomics facilitates the discovery of in vivo functional small molecules with a diversity of biological contexts.
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DOI：
10.4155/fmc.13.148
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发表时间：
2013-10
影响因子：
4.2
通讯作者：
Leyu Yan;Wenna Nie;T. Parker;Z. Upton;Haitao Lu
中科院分区：
文献类型：
--
作者：
Leyu Yan;Wenna Nie;T. Parker;Z. Upton;Haitao Lu
体内小分子作为必需的中间体参与许多关键的代谢途径和与许多基本生物学功能和事件相关的生物学过程。越来越多的证据表明，基于MS的代谢组学正在成为一个强大的工具，以促进发现功能性小分子，可以更好地了解我们的发展，感染，营养，疾病，毒性，药物治疗，基因修饰和宿主-病原体相互作用从代谢的角度。然而，由于现有技术和知识的不足，基于MS的代谢组学仍需进一步发展。这一技术驱动的审查旨在探索在体内的功能性小分子的发现促进MS为基础的代谢组学，并强调这种发现策略的分析能力和有前途的应用。此外，在体内功能的小分子与不同的生物背景的发现的生物学意义也询问在代谢的角度。
In vivo small molecules as necessary intermediates are involved in numerous critical metabolic pathways and biological processes associated with many essential biological functions and events. There is growing evidence that MS-based metabolomics is emerging as a powerful tool to facilitate the discovery of functional small molecules that can better our understanding of development, infection, nutrition, disease, toxicity, drug therapeutics, gene modifications and host-pathogen interaction from metabolic perspectives. However, further progress must still be made in MS-based metabolomics because of the shortcomings in the current technologies and knowledge. This technique-driven review aims to explore the discovery of in vivo functional small molecules facilitated by MS-based metabolomics and to highlight the analytic capabilities and promising applications of this discovery strategy. Moreover, the biological significance of the discovery of in vivo functional small molecules with different biological contexts is also interrogated at a metabolic perspective.