Older age is a risk factor associated with poor prognosis of patients with squamous cell carcinoma of the oral cavity
Older age is a risk factor associated with poor prognosis of patients with squamous cell carcinoma of the oral cavity
复制标题
年龄较大是口腔鳞状细胞癌患者预后不良的危险因素
DOI：
10.1007/s00405-020-05963-3
复制
发表时间：
2020-04-22
影响因子：
2.6
通讯作者：
Song，Ming
中科院分区：
文献类型：
--
作者：
Chen，Shuwei;Lin，Zhu;Song，Ming
目的年轻口腔鳞状细胞癌(OC-SCC)患者的预后是否存在差异仍存在争议。本研究旨在分析40岁以下与40岁及以上成人患者的临床特点和生存率差异。方法采用中山大学肿瘤研究中心1990-2013年确诊的OC-SCC患者数据库进行回顾性分析，排除85岁以上、18岁以下及确诊后6个月内死亡的患者。患者被分为两组：青年组(40岁)和老年组(≥ )40岁。进行COX回归分析、生存分析和分组分析。主要终点包括5年总生存率(OS)和疾病特异性生存率(DSS)。青年组女性比例显著高于老年组(40.27%vs31.03%，p<； 0.001)。本研究未发现两组患者在肿瘤分期或肿瘤分期上的差异(p>； )。年轻组接受辅助放疗和/或化疗的可能性更大(42.48%vs26.91%，p<； 0.001)。40岁以下患者的5年OS率(71%比57%，p<； 0.001)和DSS率(72%比58%，p<； 0.001)显著高于老年组。此外，年轻是一个独立的预测因素，预示着更好的生存。
PurposeWhether or not young patients with squamous cell carcinoma of oral cavity (OC-SCC) have a difference in prognosis remains a controversy. This study aimed to analyze the clinical characteristics and difference of survival rates between adult patients less than 40 years of age and those 40 years of age and older.MethodsA retrospective analysis was conducted using the database of patients diagnosed with OC-SCC between 1990 and 2013 in the Sun Yat-sen University Cancer Center, but patients older than 85 years, younger than 18 years, or died within 6 months of diagnosis were excluded. Patients were categorized into two groups: the young group (< 40 years of age) and the older group (≥ 40 years of age). Cox regression, survival and subgroups analyses were performed. The primary endpoints included the rates of 5-year overall survival (OS) and disease-specific survival (DSS).ResultsA total of 1902 OC-SCC patients were identified. The percentage of female in the young group was significantly higher than that in the older group (40.27% vs 31.03%,p< 0.001). This study failed to find the difference in TNM classification or tumor stage between the two groups (p> 0.05). The young group was more likely to receive adjuvant radiotherapy and/or chemotherapy (42.48% vs 26.91%,p< 0.001). The 5-year OS rate (71% vs. 57%,p< 0.001) and DSS rate (72% vs 58%,p< 0.001) in patients under 40 years were significantly higher than those for the older group.ConclusionOur findings suggested that OC-SCC in younger patients did not present at a more advanced stage. In addition, young age is an independent predictor for better survival.