Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: The EURODIAB IDDM Complications Study
Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: The EURODIAB IDDM Complications Study
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DOI：
10.1007/s001250050586
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发表时间：
1996-11-01
期刊：
影响因子：
8.2
通讯作者：
Ward, JD
中科院分区：
文献类型：
--
作者：
Tesfaye, S;Stevens, LK;Ward, JD
EURODIAB IDDM并发症研究包括对来自16个欧洲国家31个中心的3250名随机选择的胰岛素依赖型糖尿病患者进行检查。部分检查包括神经功能评估，包括神经病性症状和体征、振动感知阈值、自主神经功能测试和阳痿患病率。整个欧洲糖尿病神经病变的患病率为28%，没有显著的地理差异。糖尿病周围神经病变的发生与年龄显著相关（p < 0.05），糖尿病病程（p < 0.001），代谢控制质量（p < 0.001），身高（p < 0.01），背景或增殖性糖尿病视网膜病变的存在（p < 0.01）、吸烟（p < 0.001）、高密度脂蛋白胆固醇（p < 0.001）和心血管疾病的存在（p < 0.05），从而证实了先前的关联。这项研究发现了新的相关性，即与舒张压升高（p < 0.05）、重度酮症酸中毒（p < 0.001）、空腹甘油三酯水平升高（p < 0.001）和微量白蛋白尿（p < 0.01）有关。所有数据均根据年龄、糖尿病病程和HbA（1c）进行调整。虽然酒精摄入与腿部反射和自主神经功能障碍的缺乏相关，但酒精摄入与神经病变之间没有总体关联。报告的阳萎问题在各中心之间差异极大，表明在不同欧洲国家收集此类信息时存在许多文化和态度差异。总之，这项研究已经确定了以前已知的和新的糖尿病周围神经病变的发展的潜在危险因素。
The EURODIAB IDDM Complications Study involved the examination of 3250 randomly se lected insulin-dependent diabetic patients, from 31 centres in 16 European countries. Part of the examination included an assessment of neurological function including neuropathic symptoms and physical signs, vibration perception threshold, tests of autonomic function and the prevalence of impotence. The prevalence of diabetic neuropathy across Europe was 28 % with no significant geographical differences. Significant correlations were observed between the presence of diabetic peripheral neuropathy with age (p < 0.05), duration of diabetes (p < 0.001), quality of metabolic control (p < 0.001), height (p < 0.01), the presence of background or proliferative diabetic retinopathy (p < 0.01), cigarette smoking (p < 0.001), high-density lipoprotein cholesterol (p < 0.001) and the presence of cardiovascular disease (p < 0.05), thus confirming previous associations. New associations have been identified from this study - namely with elevated diastolic blood pressure (p < 0.05), the presence of severe ketoacidosis (p < 0.001), an increase in the levels of fasting triglyceride (p < 0.001), and the presence of microalbuminuria (p < 0.01). All the data were adjusted for age, duration of diabetes and HbA(1c). Although alcohol intake correlated with absence of leg reflexes and autonomic dysfunction, there was no overall association of alcohol consumption and neuropathy. The reported problems of impotence were extremely variable between centres, suggesting many cultural and attitudinal differences in the collection of such information in different European countries. In conclusion, this study has identified previously known and new potential risk factors for the development of diabetic peripheral neuropathy.