Isolated single umbilical artery anomaly and the risk for congenital malformations: A meta-analysis
Isolated single umbilical artery anomaly and the risk for congenital malformations: A meta-analysis
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DOI：
10.1016/s0022-3468(98)90320-7
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发表时间：
1998-04-01
影响因子：
2.4
通讯作者：
Langenberg, P
中科院分区：
文献类型：
--
作者：
Thummala, MR;Raju, TNK;Langenberg, P
Background/Purpose: Single umbilical artery (SUA) is an associated finding in many chromosomal abnormalities and congenital malformations. However, SUA can also be seen as an isolated finding. The extent of diagnostic investigation and follow-up needed in infants with SUA as an isolated finding has long been debated, in this study the authors examined this issue by an analysis of the published papers concerning SUA anomaly.Methods: A meta-analysis of 37 studies related to SUA published over a 40-year period was performed. Eleven of 37 studies were considered group 1 because the diagnosis of SUA was made using specimens obtained from early abortuses, fetal deaths, or autopsies. The remaining 26 studies were considered group 2 because the diagnosis of SUA was made from examining placental and umbilical cord specimens obtained from live-born infants or by examination of the umbilicus soon after birth.Results: The mean (and 95% CI) SUA incidence was 2.13% (1.92%, 2.34%) in group 1, and 0.55% (0.44%, 0.66%) in group 2. The mean incidence of congenital malformation associated with SUA was 66.3% (67.7%, 70.8%) in group 1, and 27% (21.6%, 32.3%) in group 2; these differences were significant (P
