Hormonal control of distal nephron function.
Hormonal control of distal nephron function.
复制标题
远端肾单位功能的激素控制。
DOI：
10.1007/bf01738140
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Giebisch,G
中科院分区：
文献类型：
--
作者：
Giebisch,G
远曲小管和集合小管是水和电解质排泄的重要控制部位。在我们的演讲中，我们考虑了钠和钾离子的细胞运输机制以及几种激素的影响。醛固酮和抗利尿剂直接刺激钾分泌，现有证据强烈表明这种作用涉及主要细胞群。肾上腺素可抑制远曲小管以外部位的钾分泌。除了这些直接影响外，次要因素（如酒精诱导的沿远端小管的流速沿着变化和血浆钾水平变化）也发挥重要的调节作用。几个例子来证明，几个控制组件的相互作用解偶联钾分泌从远端流速，并趋于稳定尿钾排泄过程中的钠和水平衡的变化。
The distal tubule and collecting tubules are important control sites of fluid and electrolyte excretion. In our presentation we consider the cell mechanisms of transport of sodium and potassium ions and the effects of several hormones. Aldosterone and antidiuretics stimulate potassium secretion directly, and the available evidence strongly suggests that this effect involves the principal cell population. Epinephrine inhibits potassium secretion at sites beyond the distal tubule. In addition to such direct effects, secondary factors such as hormone-induced changes in flow rate along the distal tubule and changes in the plasma potassium level play an important modifying role. Several examples are presented to demonstrate that interaction of several control components uncouples potassium secretion from distal flow rate and tends to stabilize urinary potassium excretion during changes in sodium and water balance.