Control of lymphocyte trafficking and adaptive immunity by adrenergic nerves
Control of lymphocyte trafficking and adaptive immunity by adrenergic nerves
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肾上腺素能神经控制淋巴细胞运输和适应性免疫
DOI：
10.1111/cen3.12376
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
A.
中科院分区：
文献类型：
--
作者：
Suzuki;K. and Nakai;A.
神经系统和免疫系统是感知内部和外部环境的主要器官系统，并引起适应性反应以维持稳态。过去几十年的研究发现了这两个器官系统之间的共同点。它们共享许多功能分子，并以高度特异性响应各种刺激。此外，长期以来，人们一直认为神经系统和免疫系统之间也存在串扰。然而，神经免疫相互作用的细胞和分子基础只是在过去十年才出现。肾上腺素能神经构成交感神经系统的传出弧并协调整个身体中的器官功能。最近的研究表明，肾上腺素能神经通过不同的分子机制调节骨髓和淋巴免疫细胞的运输。在本综述中，我们集中在生理和病理条件下，肾上腺素能神经在控制淋巴细胞运输和适应性免疫反应中的作用。
The nervous and immune systems are the principal organ systems that sense internal and external environments, and evoke adaptive responses to maintain homeostasis. Studies in the past few decades discovered commonalities between the two organ systems. They share many functional molecules and respond to various stimuli with high specificity. Additionally, it has long been suggested that there is also cross‐talk between the nervous and immune systems. However, the cellular and molecular basis for neuroimmune interactions has emerged only in the past decade. Adrenergic nerves constitute the efferent arc of the sympathetic nervous system and coordinate organ functions in the entire body. Recently, studies have shown that adrenergic nerves regulate the trafficking of myeloid and lymphoid immune cells through distinct molecular mechanisms. In the present review, we focus on the role of adrenergic nerves in the control of lymphocyte trafficking and adaptive immune responses in physiological and pathological conditions.