Effects of lactoferrin in 6 patients with refractory bacterial vaginosis
Effects of lactoferrin in 6 patients with refractory bacterial vaginosis
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DOI：
10.1139/bcb-2016-0051
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发表时间：
2017-02-01
影响因子：
2.9
通讯作者：
Imai, Noriaki
中科院分区：
文献类型：
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作者：
Otsuki, Katsufumi;Imai, Noriaki
我们之前报道了乳铁蛋白（LF）可以有效预防早产和宫内感染，基于小鼠和兔子的数据。本文报告了6例有多胎流产或早产史和难治性细菌性阴道病的妇女，她们接受了益生元LF治疗并正常分娩。在这项研究中，五名妇女怀孕了，一名没有怀孕。昭和大学医院和昭和大学Koto Toyosu医院的伦理委员会批准了治疗方案。阴道栓剂和口服益生元LF用于难治性阴道炎和绒毛膜羊膜炎导致晚期流产和早期早产的难治性阴道炎患者。LF显著改善阴道菌群。乳杆菌，在LF治疗一个月后，在所有患者的阴道中检测到，逐渐成为优势。这6例患者的研究结果表明，给人服用LF有助于预防难治性阴道炎、宫颈炎症和早产。
We previously reported that lactoferrin (LF) could be effective for preventing preterm delivery and intrauterine infections, based on data derived from mice and rabbits. Here we describe 6 women with a history of multiple pregnancy losses or preterm delivery and refractory bacterial vaginosis, who received prebiotic LF therapy and delivered an infant normally. Five of the women were pregnant and one was not at the time of this study. The Ethics Committee at Showa University Hospital and Showa University Koto Toyosu Hospital approved the therapeutic protocol. Vaginal suppositories and oral prebiotic LF were administered to patients who were refractory to conventional treatment for vaginosis and had a history of late miscarriages and very early preterm delivery due to refractory vaginitis and chorioamnionitis. LF significantly improved the vaginal bacterial flora. Lactobacillus, which was detectable in the vaginas of all patients after one month of LF therapy, gradually became dominant. The findings from these 6 patients suggest that administering LF to humans could help prevent refractory vaginitis, cervical inflammation, and preterm delivery.