Community-associated meticillin-resistant Staphylococcus aureus.
Community-associated meticillin-resistant Staphylococcus aureus.
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DOI：
10.1016/s0140-6736(09)61999-1
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发表时间：
2010-05-01
期刊：
影响因子：
168.9
通讯作者：
Chambers, Henry F.
中科院分区：
文献类型：
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作者：
DeLeo, Frank R.;Otto, Michael;Kreiswirth, Barry N.;Chambers, Henry F.
耐甲氧西林金黄色葡萄球菌(MRSA)在世界各地的医院流行，是发病率和死亡率的重要原因。与医疗保健相关的MRSA感染发生在具有疾病易感风险因素的个人中，例如手术或存在留置医疗器械。相比之下，社区相关耐甲氧西林金黄色葡萄球菌(CA-MRSA)感染通常发生在缺乏此类危险因素的其他健康个人中。此外，CA-MRSA感染在一些国家流行。这些观察表明，CA-MRSA菌株比传统的医院相关MRSA菌株更具毒力和传播性。CA-MRSA感染的治疗选择相对有限，加剧了毒力增强和传播的问题。尽管在了解CA-MRSA的出现、毒力和感染的治疗方面已经取得了进展，但我们在这些领域的知识仍然不完整。这里回顾了这些领域的最新知识，并对CA-MRSA感染的预防和/或新疗法的未来前景进行了展望。
Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in hospitals worldwide and a significant cause of morbidity and mortality. Healthcare-associated MRSA infections occur in individuals with predisposing risk factors for disease, such as surgery or presence of an indwelling medical device. By contrast, community-associated MRSA (CA-MRSA) infections often occur in otherwise healthy individuals who lack such risk factors. In addition, CA-MRSA infections are epidemic in some countries. These observations suggest that CA-MRSA strains are more virulent and transmissible than traditional hospital-associated MRSA strains. Relatively limited treatment options for CA-MRSA infections compound the problem of enhanced virulence and transmission. Although progress has been made toward understanding emergence of CA-MRSA, virulence, and treatment of infections, our knowledge in these areas remains incomplete. Here were review the most current knowledge in these areas and provide perspective on future outlook for prophylaxis and/or new therapies for CA-MRSA infections.