Anti-babesial compounds from Curcuma zedoaria
Anti-babesial compounds from Curcuma zedoaria
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DOI：
10.1055/s-2005-871216
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发表时间：
2005-05-01
期刊：
影响因子：
2.7
通讯作者：
Yoshihara, T
中科院分区：
文献类型：
--
作者：
Kasahara, K;Nomura, S;Yoshihara, T
在莪术树皮提取物中证实了抗巴贝斯虫活性。分离活性成分，并根据光谱数据确定其化学结构为zecloalactone A、B和C。Zedoalactone C是一种迄今未见报道的化合物。将这些活性化合物对吉氏巴氏巴氏线虫的IC 50值与标准药物醋酸亚胺氮烯进行比较。乙酰氨基二氮烯的IC 50值为0.6 μ g/mL，而莪术内酯A、B和C的IC 50值分别为16.5、1.6和4.2 μ g/mL。
Anti-babesial activity was confirmed in an extract of the bark of Curcuma zedoaria. The active ingredients were isolated, and their chemical structures were determined to be zecloalactones A, B, and C based on spectral data. Zedoalactone C is a hitherto unreported compound. The IC50 vales of these active compounds against Babesia gibsoni were compared with a standard drug, diminazene aceturate. The IC50 value of diminazene aceturate was 0.6 mu g/mL, while those of zedoalactones A, B, and C were 16.5,1.6 and 4.2 mu g/mL, respectively.