Splenic Macrophage Subsets and Their Function during Blood-Borne Infections.
Splenic Macrophage Subsets and Their Function during Blood-Borne Infections.
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DOI：
10.3389/fimmu.2015.00480
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发表时间：
2015
影响因子：
7.3
通讯作者：
D'Império Lima MR
中科院分区：
文献类型：
--
作者：
Borges da Silva H;Fonseca R;Pereira RM;Cassado Ados A;Álvarez JM;D'Império Lima MR
脾是维持血液动态平衡的主要免疫学部位之一。以前的研究表明，异种脾巨噬细胞群体在控制血液传播感染和诱导有效的免疫反应方面起到了有益的作用。边缘嗜金属巨噬细胞(MmmΦS)和边缘带巨噬细胞(MZMΦS)是对病毒或细菌等血液传播病原体具有很强内化能力的细胞。它们位于富含T和B细胞的脾区域附近，有利于这些巨噬细胞与获得性免疫细胞之间的快速接触。事实上，ΦS和MZMΦS被认为是先天免疫和获得性免疫之间的重要桥梁。虽然红髓巨噬细胞(rpmΦS)主要被认为是衰老红细胞的清道夫，但一些数据表明rpmΦS在控制血液期疟疾等感染以及诱导天然免疫和获得性免疫方面发挥了作用。在这里，我们回顾了关于不同的巨噬细胞亚群如何识别和帮助消除血液传播的病原体，以及感染不同阶段(急性、慢性和病原体清除后)的炎症微环境如何影响巨噬细胞功能和生存的最新数据。
The spleen is one of the major immunological sites for maintaining blood homeostasis. Previous studies showed that heterogeneous splenic macrophage populations contribute in complimentary ways to control blood-borne infections and induce effective immune responses. Marginal metallophilic macrophages (MMMΦs) and marginal zone macrophages (MZMΦs) are cells with great ability to internalize blood-borne pathogens such as virus or bacteria. Their localization adjacent to T- and B-cell-rich splenic areas favors the rapid contact between these macrophages and cells from adaptive immunity. Indeed, MMMΦs and MZMΦs are considered important bridges between innate and adaptive immunity. Although red pulp macrophages (RpMΦs) are mainly considered scavengers for senescent erythrocytes, several data indicate a role for RpMΦs in control of infections such as blood-stage malaria as well as in the induction of innate and adaptive immunity. Here, we review current data on how different macrophage subsets recognize and help eliminate blood-borne pathogens, and, in turn, how the inflammatory microenvironment in different phases of infection (acute, chronic, and after pathogen clearance) influences macrophage function and survival.