HUMAN GROWTH-HORMONE PREVENTS THE PROTEIN CATABOLIC SIDE-EFFECTS OF PREDNISONE IN HUMANS
HUMAN GROWTH-HORMONE PREVENTS THE PROTEIN CATABOLIC SIDE-EFFECTS OF PREDNISONE IN HUMANS
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DOI：
10.1172/jci114694
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发表时间：
1990-07-01
影响因子：
15.9
通讯作者：
HAYMOND, MW
中科院分区：
文献类型：
--
作者：
HORBER, FF;HAYMOND, MW
泼尼松治疗会导致蛋白质浪费，并增加患者的风险，而人类生长激素(HGH)治疗会导致正氮平衡。为了确定同时服用hGH是否能阻止泼尼松的蛋白质分解作用，四组8名健康志愿者在服用安慰剂7d后，采用同位素稀释和氮平衡技术进行了研究，其中hGH单独服用(0.1mg.cntdot)。Kg-1)，单用强的松(0.8 mg.Kg-1.cntdo.D-1)，或强的松+hGH组(n=8)。无论是根据亮氨酸动力学数据还是氮平衡值计算蛋白质平衡，与安慰剂组相比，泼尼松单独导致蛋白质消耗(P<；0.001)，而hGH单独导致正蛋白质平衡(P<；0.001)。在强的松治疗中加入hGH，可阻止糖皮质激素诱导的蛋白质分解代谢。根据亮氨酸动力学数据，泼尼松时蛋白质负平衡是由于蛋白质分解增加(P<；0.05)，而hGH对蛋白质分解没有影响，而增加了全身蛋白质合成(P<；0.01)。在联合治疗期间，蛋白质分解和蛋白质合成的估计与安慰剂对照组观察到的相似。综上所述，人类生长激素可能在防止人类服用药理剂量的糖皮质激素相关的蛋白质损失方面具有独特的作用。
Prednisone treatment causes protein wasting and adds additional risks to a patient, whereas human growth hormone (hGH) treatment causes positive nitrogen balance. To determine whether concomitant administration of hGH prevents the protein catabolic effects of prednisone, four groups of eight healthy volunteers each were studied using isotope dilution and nitrogen balance techniques after 7 d of placebo, hGH alone (0.1 mg .cntdot. kg-1), prednisone alone (0.8 mg .cntdot. kg-1 .cntdot. d-1), or prednisone plus hGH (n = 8) in each group). Whether protein balance was calculated from the leucine kinetic data or nitrogen balance values, prednisone alone induced protein wasting (P < 0.001), whereas hGH alone resulted in positive (P < 0.001) protein balance, when compared to the placebo-treated subjects. When hGH was added to prednisone therapy, the glucocorticoid-induced protein catabolism was prevented. Using leucine kinetic data, negative protein balance during prednisone was due to increased (P < 0.05) proteolysis, whereas hGH had no effect on proteolysis and increased (P < 0.01) whole body protein synthesis. During combined treatment, estimates of proteolysis and protein synthesis were similar to those observed in the placebo treated control group. In conclusion, human growth hormone may have a distinct role in preventing the protein losses associated with the administration of pharmacologic doses of glucocorticosteroids in humans.