Fetal renal contribution to amniotic fluid osmolality during maternal hypertonicity.
Fetal renal contribution to amniotic fluid osmolality during maternal hypertonicity.
复制标题
母体高渗期间胎儿肾脏对羊水渗透压的贡献。
DOI：
10.1152/ajpregu.1986.250.2.r235
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Woods,LL
中科院分区：
文献类型：
--
作者：
Woods,LL
在妊娠130-135天的绵羊中，研究了在母体高渗性期间，胎儿尿液对羊水渗透压升高的贡献。将9%的NaCl同时注射到胎儿和母体静脉中，然后连续输注到母体静脉中。母体和胎仔血浆渗透压分别升高15 +/- 1（SE）和13 +/- 1 mosmol/kg，并保持恒定4 h。胎仔尿渗透压摩尔浓度在1小时内从188 +/- 31显著升高至277 +/- 32 mosmol/kg，此后保持恒定。胎儿尿流量一过性升高，10分钟内降至正常，1小时后平均为正常值的70%。4小时内羊水渗透压升高10.8 +/- 2.8 mosmol/kg。对三个被精氨酸加压素拮抗剂d（CH 2）5D-tyr（Et）VAVP阻断的胎儿进行高渗注射后，尿渗透压没有变化，羊水渗透压升高了2.7 +/- 0.3 mosmol/kg。因此，似乎在母体高渗性期间羊水渗透压的增加可能主要是由于胎儿尿渗透压增加，加上胎儿尿流入羊膜腔的流量减少，而不是大量液体流过膜和子宫壁。
The contribution of fetal urine to the increase in amniotic fluid osmolality during maternal hypertonicity was studied in chronically catheterized sheep of 130-135 days gestation. Nine percent NaCl was injected simultaneously into fetal and maternal veins, followed by a continuous infusion into the maternal vein. Maternal and fetal plasma osmolalities rose by 15 +/- 1 (SE) and 13 +/- 1 mosmol/kg, respectively, and remained constant for 4 h. Fetal urine osmolality rose significantly from 188 +/- 31 to 277 +/- 32 mosmol/kg within 1 h and remained constant thereafter. Fetal urine flow rose transiently, fell to normal within 10 min, and averaged 70% of normal beyond 1 h. Amniotic fluid osmolality rose by 10.8 +/- 2.8 mosmol/kg over 4 h. Following hypertonic injection into three fetuses blocked by the arginine vasopressin antagonist d(CH2)5D-tyr(Et)VAVP, urine osmolality did not change, and amniotic fluid osmolality rose by 2.7 +/- 0.3 mosmol/kg. Thus it appears that the increase in amniotic fluid osmolality during maternal hypertonicity may be due largely to an increased fetal urine osmolality coupled with a decreased flow of fetal urine into the amniotic space, rather than to bulk flow of fluid across the membranes and uterine wall.