Autoradiographic and small-animal PET comparisons between 18F-FMISO, 18F-FDG, 18F-FLT and the hypoxic selective 64Cu-ATSM in a rodent model of cancer
Autoradiographic and small-animal PET comparisons between 18F-FMISO, 18F-FDG, 18F-FLT and the hypoxic selective 64Cu-ATSM in a rodent model of cancer
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DOI：
10.1016/j.nucmedbio.2008.06.001
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发表时间：
2008-08-01
影响因子：
3.1
通讯作者：
Lewis, Jason S.
中科院分区：
文献类型：
--
作者：
Dence, Carmen S.;Ponde, Datta E.;Lewis, Jason S.
简介：铜（II）-二乙酰基-双（N-4-甲基缩氨基硫脲），或Cu-ATSM，一种缺氧显像剂，已被证明可预测多种肿瘤患者对传统癌症治疗的反应。众所周知，肿瘤的环境导致无数的生理后果，包括缺氧、代谢不良和增殖的改变。为了更好地表征Cu-ATSM与其他主要放射性药物之间的关系，本研究进行了比较Cu-64-ATSM与[F-18]氟咪唑的区域分布。（F-18-FMISO），[F-18]氟-2-脱氧-D-葡萄糖（F-18-FDG）和[F-18]氟胸苷（（FLT）-F-18）。结果表明，F-18-FMISO和Cu-64-ATSM的区域分布在Cu-64-ATSM允许分布10 min或10 min时显示出极好的相关性，（R-2 = .84）或24 h（R-2 = .86）。Cu-64-ATSM（10分钟）和F-18-FDG（1小时）之间的区域比较导致两种药物的区域摄取之间的相关性非常差（R-2 = 0.08）。F-18-FLT和Cu-64-ATSM之间的比较显示两种示踪剂之间的强相关性（R-2=.83）。Cu-64-ATSM和F-18-FMISO和F-18-FLT之间的分布比较的小动物PET图像与从文件放射自显影studies.Conclusions产生的数据一致：数据显示，重要的是要记住，当考虑到高葡萄糖摄取，增殖和缺氧区域之间的关系时，可以存在一些不同的代谢情况。(C)2008年爱思唯尔公司All rights reserved.
Introduction: Copper(II)-diacetyl-bis(N-4-methylthiosemicarbazone), or Cu-ATSM, a hypoxia imaging agent, has been shown to be predictive of response to traditional cancer therapies in patients with a wide range of tumors. It is known that the environment of the tumor results in a myriad of physiological consequences, including hypoxia, alterations ill metabolism and proliferation In all effort to better characterize the relationships between Cu-ATSM and other prominent radiopharmaceuticals, this current study was undertaken to compare the regional distribution of Cu-64-ATSM with [F-18]fluoromisonidazole (F-18-FMISO), [F-18]fluoro-2-deoxy-D-glucose (F-18-FDG) and [F-18] fluorothymidine ((FLT)-F-18) in 9L tumors.Results: It was shown that the regional distribution of F-18-FMISO all Cu-64-ATSM showed an excellent correlation when file Cu-64-ATSM had been allowed to distribute for either 10 min (R-2 = .84) or 24 h (R-2 = .86). The regional comparisons between Cu-64-ATSM (10 min) and F-18-FDG (1 h) resulted in a very poor correlation (R-2 = .08) between the regional uptake of the two agents. The comparison between F-18-FLT and Cu-64-ATSM showed a strong relationship (R-2=.83) between the two tracers. The small-animal PET images for the distribution comparisons between Cu-64-ATSM and F-18-FMISO and F-18-FLT were in agreement with the data generated from file autoradiography studies.Conclusions: The data show that it is important to remember that a number of different metabolic situations can exist when considering the relationship between regions of high glucose uptake, proliferation and hypoxia. (C) 2008 Elsevier Inc. All rights reserved.