Characterization of the intra-prostatic immune cell infiltration in androgen-deprived prostate cancer patients
Characterization of the intra-prostatic immune cell infiltration in androgen-deprived prostate cancer patients
复制标题
DOI：
10.1016/j.jim.2009.06.004
复制
发表时间：
2009-08-31
影响因子：
2.2
通讯作者：
Saad, Fred
中科院分区：
文献类型：
--
作者：
Gannon, Philippe O.;Poisson, Alexis O.;Saad, Fred
简介：我们的目标是使用优化的计算机辅助量化方法研究接受雄激素剥夺疗法（ADT）治疗的前列腺癌患者免疫细胞浸润的激素调节。方法：免疫细胞亚型（CD3（+）、CD8（+）、CD20（+）、CD56（+）、通过免疫组化分析来自对照患者的存档前列腺标本中的CD68（+）和Foxp3（+（仅根治性膀胱切除术，n = 40）和ADT治疗的患者（ADT根治性前列腺切除术前，n = 35）使用图像分析软件和全载玻片扫描仪。ADT治疗组患者的CD3（+）相对密度显著增加（p
Introduction: Our goal was to study the hormonal regulation of immune cell infiltration in prostate cancer patients treated by androgen deprivation therapy (ADT) using an optimized computer-assistance quantification approach.Methods: The relative density of immune cell subtypes (CD3(+), CD8(+), CD20(+), CD56(+), CD68(+) and Foxp3(+)) was analyzed by immunohistochemistry in archived prostate specimens from control patients (radical prostatectomy only, n = 40) and ADT-treated patients (ADT prior to radical prostatectomy, n = 35) using an image analysis software and a whole-slide scanner.Results: ADT-treated patients had significantly increased relative density of CD3(+) (p