The chromosomes and causation of human cancer and leukemia: XXXVIII. Cytogenetic experience in Ph1‐negative chronic myelocytic leukemia (CML)
The chromosomes and causation of human cancer and leukemia: XXXVIII. Cytogenetic experience in Ph1‐negative chronic myelocytic leukemia (CML)
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人类癌症和白血病的染色体和病因：Ph1 阴性慢性粒细胞白血病 (CML) 的细胞遗传学经验。
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
A. Sandberg
中科院分区：
文献类型：
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作者：
S. Kohno;S. Abe;A. Sandberg
在我院过去10年随访的300例慢性髓细胞白血病（CML）患者中，36例（12%）被认为是Ph1阴性CML。在其中8例患者中，白血病细胞中发现染色体异常；第四，用条带技术建立核型异常。本研究的数据和对有关Ph1阴性CML染色体变化的文献的回顾表明：1)Ph1阴性CML不存在特征性或一致的核型变化，二倍体在这种白血病中比任何其他白血病更常见；2)最常见的变化涉及C组染色体（特别是+8）；3)缺失Y在Ph1阴性CML中比在Ph1阳性CML中更少见。与急性髓母细胞白血病（AML）相比，Ph1阴性CML的核型变化更类似于Ph1阳性CML。与Ph1阳性组相比，Ph1阴性CML患者的生存期要短得多，这再次得到证实，并且先前报道的一些Ph1阴性CML特有的临床和实验室结果得到了证实。根据细胞遗传学结果，我们认为Ph1阴性CML似乎是一个独立的实体。
Among 300 patients with chronic myelocytic leukemia (CML) followed at our institute during the last ten years, 36 (12%) were thought to have Ph1‐negative CML. In eight of these patients, chromosomal abnormalities were found in the leukemic cells; in four, the karyotypic abnormalities were established with banding techniques. The data of the present study and a review of the literature regarding chromosomal changes in Ph1‐negative CML indicate that: 1) no characteristic or consistent karyotypic change is present in Ph1‐negative CML and that diploidy is more common in this than any other leukemia; 2) the most common changes involve group C chromosomes (particularly +8); and 3) a missing Y is less common in Ph1‐negative CML than in its Ph1‐positive counterpart. The karyotypic changes in Ph1‐negative CML resemble more those encountered in Ph1‐positive CML than in acute myeloblastic leukemia (AML). The much shorter survival of the Ph1‐negative CML patients vs that of the Ph1‐positive group was again substantiated, and some of the previously reported clinical and laboratory findings unique to Ph1‐negative CML were confirmed. On the basis of the cytogenetic findings it is concluded that Ph1‐negative CML appears to be an entity unto itself.