A Multifaceted Intervention to Improve Medication Adherence in Kidney Transplant Recipients: An Exploratory Analysis of the Fidelity of the TAKE IT Trial.
A Multifaceted Intervention to Improve Medication Adherence in Kidney Transplant Recipients: An Exploratory Analysis of the Fidelity of the TAKE IT Trial.
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DOI：
10.2196/27277
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发表时间：
2022-05-05
影响因子：
2.2
通讯作者：
Wolf, Michael S.
中科院分区：
文献类型：
--
作者：
Yoon, Esther S.;Hur, Scott;Curtis, Laura M.;Wynia, Aiden H.;Zheng, Pauline;Nair, Sumi S.;Bailey, Stacy C.;Serper, Marina;Reese, Peter P.;Ladner, Daniela P.;Wolf, Michael S.
Inadequate adherence to prescribed immunosuppressive medication regimens among kidney transplant recipients is common, yet interventions are needed to support patients in sustaining adequate adherence to prescribed regimens and achieving optimal transplant outcomes. We examined the preliminary fidelity of a transplant center-based, multifaceted adherence monitoring strategy known as TAKE IT. The TAKE IT strategy includes: (1) routine, online, monthly patient self-report adherence assessments; (2) care alerts directed to nurses; (3) quarterly reports monitoring tacrolimus values and adherence trends; (4) support tools tailored to specific adherence concerns. A 2-arm, patient-randomized trial is underway at two large transplant centers (N=449). To evaluate the initial fidelity of TAKE IT, we investigated patient uptake of monthly adherence assessments during the course of a 3-month period, whether any disparities emerged, and the nature of any reported adherence concerns. Among 202 patients randomized and exposed to TAKE IT for 3-months or more, 81% (164/202) completed an adherence assessment, 73% (148/202) completed at least two, and 57% (116/202) completed all monthly assessments. Overall, 50% (82/164) of kidney transplant recipients reported at least one adherence concern over the 3-month assessment period. The most common barriers were classified as regimen-related (eg, regimen complexity), cognitive (eg, forgetfulness), and medical (eg, side effects). Higher-income participants were more likely to complete all surveys compared to lower-income participants (P=.01). TAKE IT demonstrated 81% (164/202) completion of an adherence assessment, 73% (148/202) completion of at least two, and 57% (116/202) completion of all monthly assessments during this brief, initial observation period. Among those that did respond to the online assessments, the majority demonstrated sustained engagement. Additional monitoring modalities could also be offered to meet patient preferences to ensure all patients’ medication use can be properly monitored. ClinicalTrials.gov NCT03104868; https://clinicaltrials.gov/ct2/show/NCT03104868
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DOI：
10.1177/0272989x17753392
发表时间：
2018-04
期刊：
Medical decision making : an international journal of the Society for Medical Decision Making
影响因子：
--
作者：
Wolf MS;Smith SG;Pandit AU;Condon DM;Curtis LM;Griffith J;O'Conor R;Rush S;Bailey SC;Kaplan G;Haufle V;Martin D
通讯作者：
Martin D
影响因子：
8.8
作者：
Matas, A. J.;Smith, J. M.;Kasiske, B. L.
通讯作者：
Kasiske, B. L.
影响因子：
2.5
作者：
Cukor, Daniel;Ver Halen, Nisha;Salifu, Moro
通讯作者：
Salifu, Moro
影响因子：
2.5
作者：
Cossart, Amelia Rose;Staatz, Christine Elizabeth;Cottrell, William Neil
通讯作者：
Cottrell, William Neil
影响因子：
4.4
作者：
Weiss, BD;Mays, MZ;Hale, FA
通讯作者：
Hale, FA