Efficacy of mosquito nets treated with insecticide mixtures or mosaics against insecticide resistant Anopheles gambiae and Culex quinquefasciatus (Diptera: Culicidae) in Cote d'Ivoire
Efficacy of mosquito nets treated with insecticide mixtures or mosaics against insecticide resistant Anopheles gambiae and Culex quinquefasciatus (Diptera: Culicidae) in Cote d'Ivoire
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DOI：
10.1079/ber2003261
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发表时间：
2003-12-01
影响因子：
1.9
通讯作者：
Traoré-Lamizana, M
中科院分区：
文献类型：
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作者：
Hougard, JM;Corbel, V;Traoré-Lamizana, M
迄今为止，只有拟除虫菊酯杀虫剂被推荐用于防治疟疾的蚊帐。疟疾媒介对拟除虫菊酯抗药性的增加可能会降低这一重要媒介控制方法的效力。建议的抗性管理策略之一是在同一蚊帐上分别或混合使用拟除虫菊酯和非拟除虫菊酯杀虫剂。如果这两种杀虫剂之间有增效作用，混配尤其有希望，因为这将使两种杀虫剂的剂量降低，就像在实验室条件下对联苯菊酯(拟除虫菊酯)和硫氰菊酯(氨基甲酸酯)的混合物所证明的那样。在实验小屋中，对冈比亚按蚊和令人讨厌的致倦库蚊的野生种群的处理效果进行了比较，这两种蚊子都具有多重抗药性。在试验室中对4种处理进行了6个月的评估：推荐剂量为50 mg m(-2)联苯菊酯、300 mg m(-2)硫氰菊酯、300 mg m(-2)丁硫丹镶嵌在天花板上和50 mg m(-2)联苯菊酯在两侧，以及6.25 mg m(-2)硫氰菊酯和25 mg m(-2)联苯菊酯的混合物。混合处理和花叶处理对按蚊的威慑力、诱导外生性、食血抑制和总死亡率与丁硫克百威和联苯菊酯单独处理的效果没有显著差异，但比早期使用溴氰菊酯的效果更好。这些结果被认为是令人鼓舞的，因为不同类别的杀虫剂的组合可能是一种潜在的抗药性管理工具。这种混合物在降低成本和毒性方面可能具有优势。
Only pyrethroid insecticides have so far been recommended for the treatment of mosquito nets for malaria control. Increasing resistance of malaria vectors to pyrethroids threatens to reduce the potency of this important method of vector control. Among the strategies proposed for resistance management is to use a pyrethroid and a non-pyrethroid insecticide in combination on the same mosquito net, either separately or as a mixture. Mixtures are particularly promising if there is potentiation between the two insecticides as this would make it possible to lower the dosage of each, as has been demonstrated under laboratory conditions for a mixture of bifenthrin (pyrethroid) and carbosulfan (carbamate). The effect of these types of treatment were compared in experimental huts on wild populations of Anopheles gambiae Giles and the nuisance mosquito Culex quinquefasciatus Say, both of which are multi-resistant. Four treatments were evaluated in experimental huts over six months: the recommended dosage of 50 mg m(-2) bifenthrin, 300 mg m(-2) carbosulfan, a mosaic of 300 mg m(-2) carbosulfan on the ceiling and 50 mg m(-2) bifenthrin on the sides, and a mixture of 6.25 mg m(-2) carbosulfan and 25 mg m(-2) bifenthrin. The mixture and mosaic treatments did not differ significantly in effectiveness from carbosulfan and bifenthrin alone against anophelines in terms of deterrency, induced exophily, blood feeding inhibition and overall mortality, but were more effective than in earlier tests with deltamethrin. These results are considered encouraging, as the combination of different classes of insecticides might be a potential tool for resistance management. The mixture might have an advantage in terms of lower cost and toxicity.