Immobilization of natural products on glass slides by using a photoaffinity reaction and the detection of protein-small-molecule interactions
Immobilization of natural products on glass slides by using a photoaffinity reaction and the detection of protein-small-molecule interactions
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DOI：
10.1002/anie.200352164
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发表时间：
2003-01-01
影响因子：
16.6
通讯作者：
Osada, H
中科院分区：
文献类型：
--
作者：
Kanoh, N;Kumashiro, S;Osada, H
玻片上的文库：各种小分子，包括复杂的天然产物，通过光亲和反应被引入玻片（见图）。小分子保留了与相关结合蛋白相互作用的固有能力。重要的是，这种固定过程不需要特定的官能团，可以应用于各种小分子文库。
Library on a glass slide: A variety of small molecules, including complex natural products, are introduced to glass slides using a photoaffinity reaction (see picture). The small molecules retain the inherent ability to interact with the relevant binding proteins. Importantly, this immobilization procedure does not require a specific functional group, and can be applied for use with a diverse small-molecule library.