Detection of Respiration Movement Asymmetry Between the Left and Right Lungs Using Mutual Information and Transfer Entropy
Detection of Respiration Movement Asymmetry Between the Left and Right Lungs Using Mutual Information and Transfer Entropy
复制标题
使用互信息和传递熵检测左右肺之间的呼吸运动不对称性
DOI：
10.1109/access.2017.2772819
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发表时间：
2018-01-01
期刊：
影响因子：
3.9
通讯作者：
Liu，Guanzheng
中科院分区：
文献类型：
--
作者：
Zheng，Lianrong;Li，Yifan;Liu，Guanzheng
使用诊断成像，在单侧肺部疾病中发现了左右肺机械的不对称性。单侧肺疾病可能会影响两肺之间的信息交互，而这一点在肺功能研究中往往被忽视。本研究以21位受试者为研究对象，分别采集左、右肺的生物阻抗呼吸信号。结合两种呼吸信号之间的相关性和幅度的差异来验证三种类型的呼吸运动：呼吸对称性（RS），呼吸不对称I型（T1 RA）和呼吸不对称II型（T2 RA）。我们提取相关系数，互信息（MI）和传递熵（TE）来评估这三种类型的肺呼吸的肺功能。结果显示，RS的MI显著大于T1 RA和T2 RA。RS、T1 RA和T2 RA中两个方向的TE（TE（<inline-formula><tex-math notation="LaTeX">$\text{L}\to \text{R}$</tex-math></inline-formula>）和TE（<inline-formula><tex-math notation="LaTeX">$\text{R}\to \text{L}$</tex-math></inline-formula>））存在显著差异。TE（<inline-formula><tex-math notation="LaTeX">$\text{R}\to \text{L}$</tex-math></inline-formula>）随RS向T1 RA、再向T2 RA的转移而进行性增加。T1 RA和T2 RA两肺间信息传递的突出方向有显著性差异。结果表明，MI是检测呼吸对称性和不对称性的合适参数。TE是检测两次呼吸运动不对称性的有用工具。本研究结果有助于更好地理解肺通气再分布的机制，并为有效评估双肺不对称性提供新的临床指标。
Using diagnostic imaging, asymmetry in the mechanic of the left and right lungs has been discovered in unilateral lung disease. Unilateral lung disease might affect information interaction between two lungs, which is often neglected in the study of lung function. In this paper, twenty-one subjects were recruited to collect bio-impedance respiratory signals of the left and right lungs. The differences of correlation and amplitude between the two respiratory signals were combined to verify three types of respiration movement: respiration symmetry (RS), respiration asymmetry type I (T1RA), and respiration asymmetry type II (T2RA). We extracted the correlation coefficient, mutual information (MI), and transfer entropy (TE) to evaluate lung function in these three types of lung respiration. Results showed that MI was significantly larger in RS than in T1RA and T2RA. TE in both directions (TE(<inline-formula> <tex-math notation="LaTeX">$\text{L}\to \text{R}$ </tex-math></inline-formula>) and TE(<inline-formula> <tex-math notation="LaTeX">$\text{R}\to \text{L}$ </tex-math></inline-formula>)) were significantly different in RS, T1RA, and T2RA. TE(<inline-formula> <tex-math notation="LaTeX">$\text{R}\to \text{L}$ </tex-math></inline-formula>) increased progressively when shifting RS to T1RA and then to T2RA. The prominent direction of transferred information in two lungs was significantly different for T1RA and T2RA. The results indicate that MI is suitable parameters for detecting respiration symmetry and asymmetry. TE is a useful tool for detecting two respiration movement asymmetry. The results provide a better understanding of the mechanisms underlying responsible for pulmonary ventilation redistribution and could provide novel clinical markers to evaluate asymmetry of two lungs effectively.