SEX-DIFFERENCES IN HIPPOCAMPAL LONG-TERM POTENTIATION (LTP) AND PAVLOVIAN FEAR CONDITIONING IN RATS - POSITIVE CORRELATION BETWEEN LTP AND CONTEXTUAL LEARNING
SEX-DIFFERENCES IN HIPPOCAMPAL LONG-TERM POTENTIATION (LTP) AND PAVLOVIAN FEAR CONDITIONING IN RATS - POSITIVE CORRELATION BETWEEN LTP AND CONTEXTUAL LEARNING
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DOI：
10.1016/0006-8993(94)91176-2
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发表时间：
1994-10-24
期刊：
影响因子：
2.9
通讯作者：
FANSELOW, MS
中科院分区：
文献类型：
--
作者：
MAREN, S;DEOCA, B;FANSELOW, MS
三个实验研究了大鼠海马长时程增强（LTP）和巴甫洛夫恐惧条件反射的性别差异。实验1揭示了一个强大的性别差异，在戊巴比妥麻醉大鼠的齿状回穿孔路径突触诱导的LTP的幅度。这种LTP的性别差异在35和60日龄的大鼠中是明显的，并且不是贯穿通路突触传递的LTP前性别差异的结果; 20日龄的大鼠没有显示LTP。在LTP诱导过程中诱发的场电位分析显示，N-甲基-D-天冬氨酸（NMDA）受体激活的幅度与LTP的幅度高度相关的性别差异。实验2表明，男性条件更多的恐惧，测量冻结，上下文条件刺激（CSs）的条件室相比，他们的女性同行。这种性别差异的条件冻结是明显的低和高的无条件刺激（美国，电击脚）强度。实验3表明，增强的恐惧条件反射在男性是特定的上下文CSs，并包括一个更快的速度的条件反射。总之，这些实验揭示了海马LTP的大小与依赖海马的学习形式之间的正相关性。此外，他们提出了一个神经基础的性别差异，在校园依赖的学习任务。
Three experiments investigated sex differences in hippocampal long-term potentiation (LTP) and Pavlovian fear conditioning in rats. Experiment 1 revealed a robust sex difference in the magnitude of LTP induced at perforant path synapses in the dentate gyrus of pentobarbital-anesthetized rats. This sex difference in LTP was evident in rats of 35 and 60 days of age and was not the result of pre-LTP sex differences in perforant path synaptic transmission; 20-day-old rats did not show LTP. An analysis of field potentials evoked during LTP induction revealed a sex difference in the magnitude of N-methyl-D-aspartate (NMDA) receptor activation that was highly correlated with the magnitude of LTP. Experiment 2 showed that males condition more fear, measured as freezing, to the contextual conditional stimuli (CSs) of a conditioning chamber compared to their female counterparts. This sex difference in conditional freezing was apparent with both low and high unconditional stimulus (US, footshock) intensities. Experiment 3 revealed that the enhanced fear conditioning in males was specific to contextual CSs, and consisted of a more rapid rate of conditioning. Together, these experiments reveal a positive correlation between the magnitude of hippocampal LTP and a form of learning that depends on the hippocampus. Furthermore, they suggest a neural basis for sex differences in hippocampus-dependent learning tasks.