Interleukin-2, interleukin-15, and their receptors.
Interleukin-2, interleukin-15, and their receptors.
复制标题
DOI：
10.3109/08830189809042995
复制
发表时间：
1998-01-01
影响因子：
5
通讯作者：
Bamford, R
中科院分区：
文献类型：
--
作者：
Waldmann, T;Tagaya, Y;Bamford, R
IL-15和IL-2都是具有T细胞生长因子活性的细胞因子的四个α-螺旋束家族的14-15 kDa成员。与IL-2表现的模式相反，IL-15 mRNA由除T细胞以外的多种组织产生。我们已经证明IL-15的表达受多种因素的转录后调控，包括5' UTR的10个上游AUG，一个48 aa的信号肽和成熟蛋白的羧基端。IL-15利用两种不同的受体信号传导途径。在T细胞中，IL-15受体包括与IL-2共享的IL-2 R β和γ c亚基以及IL-15特异性受体IL-15 R α。然而，肥大细胞使用不与IL-2 R系统共享元件但涉及新的60-65 kDa IL-15 RX亚基的受体系统对IL-15作出应答。在肥大细胞中，IL-15信号传导涉及JAK-2和STAT-5活化，而不是IL-2和IL-15在活化的T细胞中使用的JAK-1和JAK-3以及STAT-3和STAT-5。
Both IL-15 and IL-2 are 14-15 kDa members of the four alpha-helical bundle family of cytokines that have T cell growth factor activity. In contrast to the pattern manifested by IL-2, IL-15 mRNA is produced by a wide variety of tissues other than T cells. We have demonstrated that IL-15 expression is posttranscriptionally regulated by multiple elements, including the ten upstream AUGs of the 5' UTR, a 48aa signal peptide and the carboxy-terminus of the mature protein. IL-15 utilizes two distinct receptor signaling pathways. In T cells the IL-15 receptor includes IL-2R beta and gamma c subunits shared with IL-2 as well as an IL-15 specific receptor, IL-15R alpha. However, mast cells respond to IL-15 using a receptor system that does not share elements with the IL-2R system but involves a novel 60-65 kDa IL-15RX subunit. In mast cells, IL-15 signaling involves JAK-2 and STAT-5 activation rather than the JAK-1 and JAK-3 as well as the STAT-3 and STAT-5 used by both IL-2 and IL-15 in activated T cells.