Ecological paradigms to understand the dynamics of metastasis.
Ecological paradigms to understand the dynamics of metastasis.
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DOI：
10.1016/j.canlet.2015.10.005
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发表时间：
2016-09-28
期刊：
影响因子：
9.7
通讯作者：
Pienta KJ
中科院分区：
文献类型：
--
作者：
Amend SR;Roy S;Brown JS;Pienta KJ
前列腺癌细胞非随机地扩散到骨骼形成致命转移的过程仍然未知。转移是癌细胞从原发肿瘤远距离扩散到远处继发部位的最终结果。为了转移，积极迁移的细胞必须移动。运动生态学描述了一个人在栖息地之间的迁移，而不需要有意识的决策。具体而言，该范例描述了影响转移动态过程的四个相互作用的组件：（1）施加在癌细胞上的微环境压力，（2）单个细胞如何对这些外部压力作出反应，（3）细胞的表型转换以获得运动所需的物理特性，以及（4）癌细胞导航到特定部位的能力。对这些组成部分的深入了解将导致新的治疗方法的发展，以中断以前未识别的转移步骤。
The process by which prostate cancer cells non-randomly disseminate to the bone to form lethal metastases remains unknown. Metastasis is the ultimate consequence of the long-range dispersal of a cancer cell from the primary tumor to a distant secondary site. In order to metastasize, the actively emigrating cell must move. Movement ecology describes an individual’s migration between habitats without the requirement of conscious decision-making. Specifically, this paradigm describes four interacting components that influence the dynamic process of metastasis: (1) the microenvironmental pressures exerted on the cancer cell, (2) how the individual cell reacts to these external pressures, (3) the phenotypic switch of a cell to gain the physical traits required for movement, and (4) the ability of the cancer cell to navigate to a specific site. A deeper understanding of each of these components will lead to the development of novel therapeutics targeted to interrupt previously unidentified steps of metastasis.