HIV-1 transcription and latency: an update.
HIV-1 transcription and latency: an update.
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HIV-1转录和延迟：更新。
DOI：
10.1186/1742-4690-10-67
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发表时间：
2013-06-26
期刊：
影响因子：
3.3
通讯作者：
Marcello A
中科院分区：
文献类型：
--
作者：
Van Lint C;Bouchat S;Marcello A
Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a rapid rebound of viremia. Reactivation of latently infected cells harboring transcriptionally silent but replication-competent proviruses is a potential source of persistent residual viremia in cART-treated patients. Although multiple reservoirs may exist, the persistence of resting CD4+ T cells carrying a latent infection represents a major barrier to eradication. In this review, we will discuss the latest reports on the molecular mechanisms that may regulate HIV-1 latency at the transcriptional level, including transcriptional interference, the role of cellular factors, chromatin organization and epigenetic modifications, the viral Tat trans-activator and its cellular cofactors. Since latency mechanisms may also operate at the post-transcriptional level, we will consider inhibition of nuclear RNA export and inhibition of translation by microRNAs as potential barriers to HIV-1 gene expression. Finally, we will review the therapeutic approaches and clinical studies aimed at achieving either a sterilizing cure or a functional cure of HIV-1 infection, with a special emphasis on the most recent pharmacological strategies to reactivate the latent viruses and decrease the pool of viral reservoirs.
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DOI：
10.1097/qad.0b013e32832ec1dc
发表时间：
2009-09-10
期刊：
AIDS (London, England)
影响因子：
--
作者：
Archin NM;Keedy KS;Espeseth A;Dang H;Hazuda DJ;Margolis DM
通讯作者：
Margolis DM
影响因子：
3.3
作者：
Agbottah, Emmanuel;Deng, Longwen;Dannenberg, Luke O.;Pumfery, Anne;Kashanchi, Fatah
通讯作者：
Kashanchi, Fatah
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
3.5
作者：
Bernhard, Wendy;Barreto, Kris;Sadowski, Ivan
通讯作者：
Sadowski, Ivan
影响因子：
5.5
作者：
Banerjee, Camellia;Archin, Nancie;Montano, Monty
通讯作者：
Montano, Monty