How rats perform spatial working memory tasks: Limitations in the use of egocentric and idiothetic working memory
How rats perform spatial working memory tasks: Limitations in the use of egocentric and idiothetic working memory
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DOI：
10.1080/02724990544000068
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发表时间：
2006-01-01
影响因子：
1.7
通讯作者：
Aggleton, JP
中科院分区：
文献类型：
--
作者：
Futter, JE;Aggleton, JP
在应该鼓励自我中心工作记忆的条件下，对黑暗焦虑品系的大鼠进行延迟交替训练。在两个实验中，在交叉迷宫内设置T迷宫，使得不同的臂可用于样品和测试运行。迷宫具有高度不透明的侧壁，并且在低光水平下进行测试，以便可以消除远端视觉线索。通过在样本运行和选择运行之间旋转迷宫908并且通过使用并排设置的两个相同迷宫，可以使其他空间策略无效。实验1和2表明，大鼠优先使用的地方信息，intramaze线索，方向线索，即使只有自我中心或独特的（nonmatch-to-turn）工作记忆可以成功地解决每一个试验。大鼠能够在迷宫内保持准确的位置感，即使远端线索不可见，并且动物在样品和选择运行之间移动。实验2证实，另一种大鼠品系（Long-Evans）显示出相同的学习特征。这两个实验都表明，大鼠在使用自我中心或独特的信息来交替方面非常差，并且短至10秒的保留延迟可以消除这些形式的记忆的使用。
Rats of the Dark Agouti strain were trained on delayed alternation under conditions that should encourage egocentric working memory. In two experiments a T-maze was set within a cross-maze so that different arms could be used for the sample and test runs. The maze had high opaque side-walls, and testing was conducted in low light levels so that distal visual cues might be eliminated. By rotating the maze 908 between the sample and choice run and by using two identical mazes set side by side it was possible to nullify other spatial strategies. Experiments 1 and 2 showed that rats preferentially used place information, intramaze cues, and direction cues, even though only egocentric or idiothetic (nonmatch-to-turn) working memory could successfully solve every trial. Rats were able to maintain an accurate sense of location within the maze even though distal cues were not visible and the animal was moved between the sample and choice runs. Experiment 2 confirmed that another rat strain (Long-Evans) shows the same learning profiles. Both experiments indicate that rats are very poor at using either egocentric or idiothetic information to alternate, and that retention delays as short as 10 s can eliminate the use of these forms of memory.