Differential expression of retinoid receptors in the adult mouse central nervous system
Differential expression of retinoid receptors in the adult mouse central nervous system
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DOI：
10.1016/s0306-4522(98)00342-x
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发表时间：
1999-04-01
期刊：
影响因子：
3.3
通讯作者：
Chambon, P
中科院分区：
文献类型：
--
作者：
Krezel, W;Kastner, P;Chambon, P
用免疫细胞化学方法分析了小鼠成年中枢神经系统中类维生素A受体的分布。检测到所有视黄酸受体（α、β和γ）和类维生素A X受体（α、β和γ），发现它们在端脑、间脑和菱脑的各个区域表现出特定的表达模式。用原位杂交和RNase保护试验研究了几种视黄酸受体和视黄酸X受体的蛋白定位与相应RNA转录本的分布之间的关系，结果表明视黄酸受体的表达可能受到转录后调节，这可能有助于它们在成人神经系统中的特异性定位。(C)1999年IBRO。出版社：Elsevier Science Ltd
The immunocytochemical distribution of retinoid receptors has been analysed in the mouse adult central nervous system. All retinoic acid receptors (alpha, beta and gamma) and retinoid X receptors (alpha, beta and gamma) were detected and found to exhibit specific patterns of expression in various areas of the telencephalon, diencephalon and rhombencephalon. The protein localization of several retinoic acid receptors and retinoid X receptors did not correlate with the distribution of the corresponding RNA transcripts, as studied by in situ hybridization and RNase protection assays.This suggests that the expression of retinoid receptors could be post-transcriptionally regulated, which may contribute to their specific localization in the adult nervous system. (C) 1999 IBRO. Published by Elsevier Science Ltd.