EAACI guideline: Anaphylaxis (2021 update)
EAACI guideline: Anaphylaxis (2021 update)
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DOI：
10.1111/all.15032
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发表时间：
2021-09-01
期刊：
影响因子：
12.4
通讯作者：
Roberts, Graham
中科院分区：
文献类型：
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作者：
Muraro, Antonella;Worm, Margitta;Roberts, Graham
过敏反应是一种临床紧急情况，所有的医疗专业人员都需要能够识别和处理。欧洲过敏和临床免疫学学会过敏反应多学科工作组更新了2014年的指南。该准则是利用《协定二》框架和等级办法制定的。对证据进行了系统的审查，并通过权衡利弊提出了建议。该指南由外部专家进行同行审查，并在公众咨询中进行审查。建议使用临床标准来确定过敏反应，并采集血液样本用于以后的类胰蛋白酶测定。建议立即使用肌肉注射肾上腺素作为一线治疗，并向社区患者提供肾上腺素自动注射器。应提供肾上腺素自动注射器装置的药代动力学数据。建议对有过敏风险的人进行有组织的、全面的培训。建议对医护人员进行模拟培训和视觉提示，以提高过敏反应的管理水平。有人建议，学校政策应反映过敏反应指南。治疗过敏反应的证据大多仍处于很低水平。迫切需要优先考虑有可能改善对有过敏风险的患者的管理的临床试验。
Anaphylaxis is a clinical emergency which all healthcare professionals need to be able to recognize and manage. The European Academy of Allergy and Clinical Immunology Anaphylaxis multidisciplinary Task Force has updated the 2014 guideline. The guideline was developed using the AGREE II framework and the GRADE approach. The evidence was systematically reviewed and recommendations were created by weighing up benefits and harms. The guideline was peer-reviewed by external experts and reviewed in a public consultation. The use of clinical criteria to identify anaphylaxis is suggested with blood sampling for the later measurement of tryptase. The prompt use of intramuscular adrenaline as first-line management is recommended with the availability of adrenaline autoinjectors to patients in the community. Pharmacokinetic data should be provided for adrenaline autoinjector devices. Structured, comprehensive training for people at risk of anaphylaxis is recommended. Simulation training and visual prompts for healthcare professionals are suggested to improve the management of anaphylaxis. It is suggested that school policies reflect anaphylaxis guidelines. The evidence for the management of anaphylaxis remains mostly at a very low level. There is an urgent need to prioritize clinical trials with the potential to improve the management of patients at risk of anaphylaxis.