Magnifying colonoscopy as a non-biopsy technique for differential diagnosis of non-neoplastic and neoplastic lesions
Magnifying colonoscopy as a non-biopsy technique for differential diagnosis of non-neoplastic and neoplastic lesions
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DOI：
10.3748/wjg.v12.i9.1416
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发表时间：
2006-03-07
影响因子：
4.3
通讯作者：
Fujimori, Takahiro
中科院分区：
文献类型：
--
作者：
Kato, Shigeharu;Fu, Kuang I;Fujimori, Takahiro
目的：澄清用放大结肠镜观察到的粘膜隐窝模式是否可以区分非肿瘤性息肉和肿瘤性息肉。方法：从1999年6月到2000年3月，连续纳入180名患者，通过放大结肠镜（CF-200Z，奥林巴斯光学有限公司，日本东京）诊断出210个病变。对每个病变进行放大和0.2%靛蓝胭脂红染料染色内镜检查，以观察粘膜隐窝。显示 I 型和 II 型隐窝模式的病变被认为是非肿瘤性的，并通过活检进行组织学检查，而显示 III 型至 V 型隐窝模式的病变则通过内窥镜或手术切除。研究内镜诊断与组织学诊断的相关性。结果：在内镜检查中，24个病灶呈I型或II型凹坑型，186个病灶呈III型至V型凹坑型。经组织学检查，诊断为非肿瘤性息肉26个，肿瘤性息肉184个。总体诊断准确率为99.1% (208/210)。敏感性和特异性分别为92.3%（24/26）和99.8%（184/186）。结论：放大结肠镜检查可作为一种非活检技术来区分肿瘤性和非肿瘤性息肉。 (C) 2006 年 WJG 出版社。版权所有。
AIM: To clarify whether mucosal crypt patterns observed with magnifying colonoscopy are feasible to distinguish non-neoplastic polyps from neoplastic polyps.METHODS: From June 1999 through March 2000, 180 consecutive patients with 210 lesions diagnosed with a magnifying colonoscope (CF-200Z, Olympus Optical Co., Ltd., Tokyo, Japan) were enrolled. Magnification and chromoendoscopy with 0.2% indigo-carmine dye was applied to each lesion for mucosal crypt observation. Lesions showing types I and II crypt patterns were considered non-neoplastic and examined histologically by biopsy, whereas lesions showing types III to V crypt patterns were removed endoscopically or surgically. The correlation of endoscopic diagnosis and histologic diagnosis was then investigated.RESULTS: At endoscopy, 24 lesions showed a type I or II pit pattern, and 186 lesions showed type III to V pit patterns. With histologic examination, 26 lesions were diagnosed as non-neoplastic polyps, and 184 lesions were diagnosed as neoplastic polyps. The overall diagnostic accuracy was 99.1% (208/210). The sensitivity and specificity were 92.3% (24/26) and 99.8% (184/186), respectively.CONCLUSION: Magnifying colonoscopy could be used as a non-biopsy technique for differentiating neoplastic and non-neoplastic polyps. (C) 2006 The WJG Press. All rights reserved.