Perfluoroalkyl substances and metabolic syndrome
Perfluoroalkyl substances and metabolic syndrome
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DOI：
10.1016/j.ijheh.2018.08.014
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发表时间：
2019-01-01
影响因子：
6
通讯作者：
Meiman, Jon
中科院分区：
文献类型：
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作者：
Christensen, Krista Y.;Raymond, Michelle;Meiman, Jon
背景：全氟烷基物质（PFAS）是一类用于许多工业应用和消费品的污染物。由于担心环境持久性和不良健康影响，某些PFAS受到管制或自愿限制。目的：在这项分析中，我们使用美国人口的代表性样本，研究PFAS水平及其与代谢综合征及其组分的关系。方法：PFAS水平和代谢综合征组分的数据收集自2007-2008、2009-2010、2011-2012和2013-2014年国家健康和营养检查调查周期。在参与者的血清样本中测量了12种不同的PFAS。Logistic回归模型被用来确定代谢综合征，其个别组件，和血清PFAS concentration.Results之间的关联：超过三分之一（37%）的参与者符合代谢综合征的定义，腰围增加和血糖升高是最常见的组件。在至少30%的参与者中检测到七种全氟辛烷磺酸，并在随后的分析中进行了检查（PFDA、PFOA、PFOS、PFHxS、MPAH、PFNA、PFUnDA）。浓度最高的全氟辛烷磺酸是全氟辛烷磺酸（中位数为8.4纳克/毫升），其次是全氟辛酸、全氟羟黄酸和全氟萘甲酸。在调整潜在的混杂因素后，PFNA与代谢综合征风险增加以及几个单独的成分相关，而最高水平的PFHxS与甘油三酯升高相关。其他PFAS与至少一个outcome.Conclusions的风险降低相关：PFAS和代谢综合征之间的关联是不一致的内部和跨研究。PFNA始终与该综合征组分的风险增加相关，这一发现值得进一步研究。
Background: Perfluoroalkyl substances (PFAS) are a class of contaminants used in many industrial applications and consumer products. Certain PFAS are regulated or voluntarily limited due to concern about environmental persistence and adverse health effects.Objectives: In this analysis we examine PFAS levels and their association with metabolic syndrome and its components, using a representative sample of the U.S. population.Methods: Data on PFAS levels and metabolic syndrome components were collected from the 2007-2008, 2009-2010, 2011-2012, and 2013-2014 cycles of the National Health and Nutrition Examination Survey. Twelve different PFAS were measured in serum samples from participants. Logistic regression models were used to identify associations between metabolic syndrome, its individual components, and serum PFAS concentrations.Results: Over one-third (37%) of participants met the definition for metabolic syndrome, with increased waist circumference and elevated glucose being the most commonly reported components. Seven PFAS were detected in at least 30% of participants and were examined in subsequent analyses (PFDA, PFOA, PFOS, PFHxS, MPAH, PFNA, PFUnDA). The PFAS with the highest concentrations was PFOS (median 8.4 ng/mL), followed by PFOA, PFHXS and PFNA. After adjusting for potential confounders, PFNA was associated with increased risk of metabolic syndrome and well as several individual components, while the highest levels of PFHxS were associated with elevated triglycerides. Other PFAS were associated with decreased risk of at least one outcome.Conclusions: Associations between PFAS and metabolic syndrome are inconsistent within and across studies. PFNA was consistently associated with increased risk for components of the syndrome, a finding that warrants further investigation.