Localized and lateralized cerebral glucose metabolism associated with eye movements during REM sleep and wakefulness: a positron emission tomography (PET) study.
Localized and lateralized cerebral glucose metabolism associated with eye movements during REM sleep and wakefulness: a positron emission tomography (PET) study.
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DOI：
10.1093/sleep/18.7.570
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发表时间：
1995-09
期刊：
影响因子：
5.6
通讯作者：
Charles Chong-Hwa Hong;J. Gillin;B. Dow;Joseph C. Wu;M. Buchsbaum
中科院分区：
文献类型：
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作者：
Charles Chong-Hwa Hong;J. Gillin;B. Dow;Joseph C. Wu;M. Buchsbaum
为了研究快速眼动（REM）睡眠期间眼动的神经基质，我们分析了从正常受试者获得的正电子发射断层扫描（18氟脱氧葡萄糖正电子发射断层扫描）扫描数据。在夜间REM睡眠期间研究的9名受试者和在清醒期间研究的6名对照受试者的眼动数据，因为他们定期移动眼睛。快速眼动睡眠期间的眼球运动次数与对应于（a）扫视眼球运动系统的区域中的葡萄糖代谢率呈正相关（额叶眼区和背外侧前额叶皮层，仅在右侧具有统计学显著性），（B）中线注意系统（扣带和内侧额叶皮层，楔前叶）和（c）顶叶视觉空间注意系统（双侧顶上级小叶，右侧顶下层小叶），与左侧顶下层小叶的相对代谢率呈负相关。除顶下小叶外，其余脑区的清醒眼动与代谢率呈正相关。我们的研究结果表明，相同的皮层区域参与眼球运动在快速眼动睡眠和清醒，并建议快速眼动睡眠眼球运动扫视扫描的目标在梦中的场景。我们的数据还表明，在较高的皮质功能，在对侧同源区的扫视眼球运动控制和相互抑制的右半球专业化。
In order to study the neural substrate for eye movements during rapid eye movement (REM) sleep, we analyzed the positron emission tomography (18Fluorodeoxyglucose positron emission tomography) scan data obtained from normal subjects. Eye movement data were available on nine subjects studied during nighttime REM sleep and six control subjects studied during waking as they periodically moved their eyes. The number of eye movements during REM sleep was positively correlated with glucose metabolic rate in the areas corresponding to (a) the saccadic eye movement system (frontal eye field and dorsolateral prefrontal cortex, statistically significant only on the right side), (b) the midline attentional system (cingulate and medial frontal cortex, precuneus) and (c) the parietal visual spatial attentional system (bilateral superior parietal lobules, right inferior parietal lobule); and negatively correlated with relative metabolic rate in the left inferior parietal lobule. Positive correlations between waking eye movements and metabolic rate were observed in the same areas except inferior parietal lobule. Our results show that the same cortical areas are involved in eye movements in both REM sleep and wakefulness and suggest that REM sleep eye movements are saccadic scans of targets in the dream scene. Our data also suggest right hemispheric specialization in saccadic eye movement control and reciprocal inhibition in the contralateral homologous area during higher cortical functioning.