Doubly cross-linked nanocellulose hydrogels with excellent mechanical properties
Doubly cross-linked nanocellulose hydrogels with excellent mechanical properties
复制标题
具有优异机械性能的双交联纳米纤维素水凝胶
DOI：
10.1007/s10570-019-02689-2
复制
发表时间：
2019
期刊：
影响因子：
5.7
通讯作者：
Xiong Chuanxi
中科院分区：
文献类型：
--
作者：
Xu Haiyu;Liu Yan;Xie Yuanyuan;Zhu Enwen;Shi Zhuqun;Yang Quanling;Xiong Chuanxi
摘要水凝胶主要应用于生物医学领域，如组织工程、药物输送和体外诊断。纳米纤维素水凝胶由于其生物降解性、无毒特性、高含水量和固有的生物相容性而具有多种优点。此外，2，2，6，6-四甲基哌啶基-1-氧基（克里思）-氧化的纤维素纳米纤丝（TOCN）是完全个体化的纤维素纳米纤丝，其具有高纵横比、高弹性模量、高强度、高热稳定性、大表面积和在其表面上的大量羧酸酯基团。在这里，制备了具有离子和化学交联的双交联（DC）纳米纤维素水凝胶，并且其机械性能比单交联纳米纤维素水凝胶表现出更多的改善。单一Fe 3+交联的纳米纤维素水凝胶和化学交联的纳米纤维素水凝胶分别在117 kPa（应变= 80%）和17 kPa（应变= 40%）的应力下断裂。DC纳米纤维素水凝胶超过450 kPa的压缩强度和90%的压缩应变而不开裂。这大大扩展了纳米纤维素水凝胶的应用。此外，这些纳米纤维素水凝胶具有良好的光学透明性和高溶胀度，以满足实际应用的需要。这些DC纳米纤维素水凝胶在生物医用材料领域具有很大的应用前景。
AbstractHydrogels are mostly used in biomedical sciences such as tissue engineering, drug delivery, and in vitro diagnostics. Nanocellulose hydrogels have multiple advantages because of their biodegradability, non-toxic properties, high water content and inherent biocompatibility. Moreover, 2,2,6,6-tetramethylpiperidinyl-1-oxyl(TEMPO)-oxidized cellulose nanofibrils (TOCNs) are completely individualized cellulose nanofibrils which have high aspect ratios, high elastic moduli, high strengths, high thermal stability, large surface areas, and large numbers of carboxylate groups on their surfaces. Here, the doubly cross-linked (DC) nanocellulose hydrogels with both ionic and chemical crosslinks were prepared and exhibited more improvement in mechanical properties than singly cross-linked nanocellulose hydrogels. The singly Fe3+cross-linked nanocellulose hydrogel and chemically cross-linked nanocellulose hydrogel were broken at stresses of 117 kPa (strain = 80%) and 17 kPa (strain = 40%), respectively. The DC nanocellulose hydrogel exceeded a compressive strength of 450 kPa and a compressive strain of 90% without cracking. This greatly expands the application of nanocellulose hydrogels. Additionally, these nanocellulose hydrogels had good optical transparency and high swelling degree to meet the needs of practical applications. These DC nanocellulose hydrogels have great application prospects in the field of biomedical materials.Graphic abstract