Gold‐Catalyzed Multicomponent Reaction: Facile Strategy for the Synthesis of N‐Substituted 1,4‐Dihydropyridines by Using Activated Alkynes, Aldehydes, and Methanamine
Gold‐Catalyzed Multicomponent Reaction: Facile Strategy for the Synthesis of N‐Substituted 1,4‐Dihydropyridines by Using Activated Alkynes, Aldehydes, and Methanamine
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DOI：
10.1002/ejoc.201301203
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发表时间：
2013-11
影响因子：
2.8
通讯作者：
Shaohua Wang;Huoji Chen;Hong Zhao;H. Cao;Yongjian Li;Qiang Liu
中科院分区：
文献类型：
--
作者：
Shaohua Wang;Huoji Chen;Hong Zhao;H. Cao;Yongjian Li;Qiang Liu
在金催化的多组分反应中，合成了一系列具有生物活性的N-取代1，4-二氢吡啶类化合物。该方法在温和条件下使用市售底物顺利进行，并以良好至优异的产率提供所需产物。该方法提供了一种由活化的炔、醛和甲胺合成N-取代的1，4-二氢吡啶的高效途径，这是催化方法稀缺的。
A convenient and efficient gold-catalyzed multicomponent reaction was developed for the synthesis of a wide range of N-substituted 1,4-dihydropyridines, which are found in a variety of bioactive compounds. This process proceeds smoothly under mild conditions with the use of commercially available substrates and affords the desired products in good to excellent yields. This method provides a highly efficient synthetic route to N-substituted 1,4-dihydropyridines from activated alkynes, aldehydes, and methanamine for which catalytic approaches are scarce.