Paradoxical response to nebulised salbutamol in wheezy infants, assessed by partial expiratory flow-volume curves.
Paradoxical response to nebulised salbutamol in wheezy infants, assessed by partial expiratory flow-volume curves.
复制标题
通过部分呼气流量-容积曲线评估喘息婴儿对雾化沙丁胺醇的反常反应。
DOI：
10.1136/thx.42.2.86
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发表时间：
1987
期刊：
影响因子：
10
通讯作者：
Michael Silverman
中科院分区：
文献类型：
--
作者：
A. Prendiville;S. Green;Michael Silverman
在18名3-15个月的慢性或复发性喘息婴儿中，通过使用充气夹克进行部分用力呼气流量-容积操作，研究了雾化支气管扩张剂对下气道的反应。以功能残气量最大流量（VmaxFRC）作为评价胸内气道功能的指标。还测量了呼气峰流速。在婴儿全身体积描记器中测定安静呼吸时的基线气道阻力和肺容量。在雾化沙丁胺醇2.5 mg之前和之后的不同日期进行测量，雾化盐水作为对照。结果是矛盾的：生理盐水后VmaxFRC没有变化，但沙丁胺醇后VmaxFRC显著下降。呼气峰流量保持不变。这些观察结果表明，在强制呼气条件下，雾化支气管扩张剂治疗喘息婴儿可能会进一步损害胸内气道功能。当使用雾化支气管扩张药物治疗婴儿期严重气道阻塞时，仔细监测是必不可少的。
Lower airway responses to nebulised bronchodilators were studied in 18 chronically or recurrently wheezy infants, aged 3-15 months, by means of partial forced expiratory flow-volume manoeuvres performed with an inflatable jacket. Maximum flow at functional residual capacity (FRC) (VmaxFRC) was used as the index of intrathoracic airways function. Peak expiratory flow rate was also measured. Baseline airways resistance and lung volume were determined during quiet breathing in an infant whole body plethysmograph. Measurements were made on separate days before and after nebulised salbutamol 2.5 mg with nebulised saline as control. The results were paradoxical: there was no change in VmaxFRC after saline, but a significant decline in VmaxFRC was found after salbutamol. Peak expiratory flow remained unchanged. These observations suggest that under conditions of forced expiration intrathoracic airways function may be further impaired by nebulised bronchodilator treatment in wheezy infants. When nebulised bronchodilator drugs are used to treat severe airways obstruction in infancy, careful monitoring is essential.