Cobalt-Catalyzed Regio- and Enantioselective Allylic Amination
Cobalt-Catalyzed Regio- and Enantioselective Allylic Amination
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钴催化的区域选择性和对映选择性烯丙基胺化
DOI：
10.1021/jacs.9b06035
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发表时间：
2019-07-24
影响因子：
15
通讯作者：
Li, Changkun
中科院分区：
文献类型：
--
作者：
Ghorai, Samir;Chirke, Sahadev Shrihari;Li, Changkun
第一个地球上丰富的钴催化的高度支化和对映选择性烯丙基胺化外消旋支化烯丙基碳酸酯携带的烷基与芳香族和脂肪族胺已经开发。该方法允许在温和的反应条件下以高收率快速获得烯丙基胺，具有专门的支化选择性和优异的对映选择性（通常99%ee）。
The first earth-abundant cobalt-catalyzed highly branched- and enantioselective allylic amination of racemic branched allylic carbonates bearing alkyl groups with both aromatic and aliphatic amines has been developed. The process allows rapid access of allylic amines in high yields with exclusively branched selectivity and excellent enantioselectivities (normally 99% ee) under mild reaction conditions.