Changes in Dynamic Insulin and Gastrointestinal Hormone Secretion in Obese Children
Changes in Dynamic Insulin and Gastrointestinal Hormone Secretion in Obese Children
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DOI：
10.1515/jpem.2010.204
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发表时间：
2010-12-01
影响因子：
1.4
通讯作者：
Woelfle, Joachim
中科院分区：
文献类型：
--
作者：
Roth, Christian L.;Bongiovanni, Kathleen D.;Woelfle, Joachim
背景：肥胖儿童饱腹感和饥饿感紊乱已有报道，但有关激素介质动态变化的数据很少。目的：通过0~180min的口服葡萄糖耐量试验，评价肥胖和瘦儿童胰岛素、Ghrelin、多肽-YY(PYY)和胰淀素的分泌模式。结果：与治疗前相比，瘦肉组大鼠血清Ghrelin酰化水平显著降低(P
Background: Disturbed satiety and hunger perception in obese individuals has been reported, however data on the dynamic changes of hormonal mediators are sparse.Objective: To evaluate the secretion pattern of insulin, ghrelin, peptide-YY (PYY), and amylin via 0 to 180 min oral glucose tolerance testing in obese and lean children.Subjects and Methods: A prospective clinical study was conducted on lean (n=9) and obese (n=20) Caucasian children of comparable age, gender, and pubertal stage. Serial blood samples were collected.Results: Compared to baseline, levels of acylated ghrelin showed a significant decrease in lean (p