AACR centennial series: the biology of cancer metastasis: historical perspective.
AACR centennial series: the biology of cancer metastasis: historical perspective.
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DOI：
10.1158/0008-5472.can-10-1040
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发表时间：
2010-07-15
期刊：
影响因子：
11.2
通讯作者：
Fidler IJ
中科院分区：
文献类型：
--
作者：
Talmadge JE;Fidler IJ
对治疗有抵抗力的转移是癌症死亡的主要原因。尽管近200年的研究，肿瘤转移的过程仍然存在争议。斯蒂芬佩吉特最初确定的基础上审查尸检记录的主机肿瘤相互作用的作用。他的“种子和土壤”假说在世纪后的实验研究中得到了证实，许多报告证实了这些开创性的观察。毫无疑问，对转移过程和通过该过程选择的细胞的属性的更好理解对于治疗患有全身性疾病的患者是至关重要的。在许多患者中，在诊断时已经发生转移，因此转移预防可能不相关，全身性疾病的治疗以及早期疾病患者的身份应该是我们的目标。在过去的三十年里，重新焕发活力的研究集中在转移生物学的新发现上。虽然我们对调节转移的分子事件的理解有所提高;但是，可能参与其发病机制的分子病变的相关贡献和时间仍然不清楚。开创性观察的历史和对当前争议的讨论应有助于研究人员理解宿主和选定肿瘤细胞之间复杂的多因素相互作用，这些相互作用导致致命的转移，并允许设计成功的治疗。
Metastases resistant to therapy is the major cause of death from cancer. Despite almost 200 years of study, the process of tumor metastasis remains controversial. Stephen Paget initially identified the role of host-tumor interactions on the basis of a review of autopsy records. His “seed and soil” hypothesis was substantiated a century later with experimental studies and numerous reports have confirmed these seminal observations. Inarguably, an improved understanding of the metastatic process and the attributes of the cells selected by this process are critical to the treatment of patients with systemic disease. In many patients, metastasis has occurred by the time of diagnosis, such that metastasis prevention may not be relevant, and treatment of systemic disease, as well as the identity of patients with early disease, should be our goal. During the last three decades, revitalized research has focused on new discoveries in the biology of metastasis. While our understanding of the molecular events that regulate metastasis has improved; nonetheless, the relevant contributions and timing of molecular lesion(s) potentially involved in its pathogenesis remain unclear. The history of pioneering observations and discussion of current controversies should help investigators understand the complex and multifactorial interactions between the host and selected tumor cells that contribute to fatal metastasis and allow for the design of successful therapy.