Randomized Controlled Trial of Behavioral Weight Loss and Stepped Care for Binge-Eating Disorder: 12-Month Follow-up.
Randomized Controlled Trial of Behavioral Weight Loss and Stepped Care for Binge-Eating Disorder: 12-Month Follow-up.
复制标题
DOI：
10.1002/oby.22975
复制
发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Gueorguieva R
中科院分区：
文献类型：
--
作者：
Grilo CM;White MA;Ivezaj V;Gueorguieva R
通过完成治疗后12个月的随访，检查行为减肥（BWL）和分步护理对暴食症（BED）和肥胖的长期影响。191例BED/肥胖患者随机接受6个月BWL（N=39）或阶梯式护理（N=152）。在阶梯式护理中，患者开始BWL（一个月），治疗反应者继续BWL，无反应者转为认知行为治疗，所有患者均随机（双盲）接受减肥药物或安慰剂（五个月）。在整个治疗过程中/治疗后以及6个月和12个月的随访中对患者进行独立评估。缓解率的ITT分析显示，治疗后（74.4% vs 66.5%）、6个月（38.2% vs 33.3%）或12个月（44.7% vs 41.0%）随访时，BWL和阶梯式护理无显著差异。暴饮暴食频率的混合模型表明通过治疗后显著降低，但在随访期间BWL和阶梯式护理之间没有显著变化或差异。混合模型显示，治疗后BWL和阶梯式护理之间无显著差异（5.1% vs 5.8%），BWL和阶梯式护理之间无显著差异（分别为-5.1% vs-5.2%和-3.4% vs-5.0%）的时间效应（6个月随访时的体重减轻百分比大于12个月随访时的体重减轻百分比）。BWL和适应性分步护理产生的暴食改善和体重减轻在完成治疗后12个月没有显著差异。
To examine longer-term effects of behavioral weight loss (BWL) and Stepped Care for binge-eating disorder (BED) and obesity through 12-month follow-up after completing treatments. 191 patients with BED/obesity were randomized to six-months of BWL (N=39) or Stepped Care (N=152). Within Stepped Care, patients began BWL (one month), treatment-responders continued BWL, non-responders switched to cognitive-behavioral therapy, and all were randomized (double-blind) to weight-loss medication or placebo (five months). Patients were independently assessed throughout/after treatment and 6- and 12-month follow-ups. ITT analyses of remission rates revealed BWL and Stepped Care did not differ significantly at post-treatment (74.4% vs 66.5%), 6-month (38.2% vs. 33.3%), or 12-month (44.7% vs 41.0%) follow-ups. Mixed-models of binge-eating frequency indicated significant reductions through post-treatment, but no significant changes nor differences between BWL and Stepped Care during follow-up. Mixed-models revealed significant weight-loss with no differences between BWL and Stepped Care (5.1% vs 5.8%) at post-treatment and significant time effects (larger percent weight-loss at 6- than 12-month follow-ups) that did not differ between BWL and Stepped Care (−5.1% vs −5.2% and −3.4% vs −5.0%, respectively). Binge-eating improvements and weight losses produced by BWL and adaptive Stepped Care did not differ significant 12 months after completing treatments.
登录
查看更多内容
影响因子：
4.1
作者：
Grilo, Carlos M.;Masheb, Robin M.;Garcia, Rina
通讯作者：
Garcia, Rina
影响因子：
168.9
作者：
Greenway, Frank L.;Fujioka, Ken;Dunayevich, Eduardo
通讯作者：
Dunayevich, Eduardo
影响因子：
5.9
作者：
Grilo, Carlos M.;Crosby, Ross D.;Masheb, Robin M.
通讯作者：
Masheb, Robin M.
影响因子：
5.9
作者：
Grilo, Carlos M.;White, Marney A.;Masheb, Robin M.;Gueorguieva, Ralitza
通讯作者：
Gueorguieva, Ralitza
DOI：
10.1002/oby.21975
发表时间：
2017-11
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Chao AM;Wadden TA;Gorin AA;Shaw Tronieri J;Pearl RL;Bakizada ZM;Yanovski SZ;Berkowitz RI
通讯作者：
Berkowitz RI